Studying the Genetic Predisposing Factors in the Pathogenesis of Acne Vulgaris

The 2011 document reviews the genetic predisposition to acne vulgaris, indicating that while the role of genetics is experimentally proven, the exact nature and effects of these genetic factors are not fully understood. It discusses polymorphisms in genes related to inflammation and androgen biosynthesis, such as MUC1, TNF-α, IL-1α, androgen receptor VNTR, and CYP1A1, noting that these may contribute to acne development, although findings are inconsistent across different populations. The document also mentions the IL-1A +4,845 SNP and the CYP17 -34T>C promoter polymorphism, which are associated with acne severity, and the potential role of FGFR2 mutations. It emphasizes the complexity of acne pathogenesis, the influence of environmental factors and lifestyle, and the need for more comprehensive genetic studies to fully elucidate the molecular mechanisms involved in acne.