TLDR Genetics play a role in acne, but how exactly they contribute is not fully understood.
The 2011 document reviews the genetic predisposition to acne vulgaris, indicating that while the role of genetics is experimentally proven, the exact nature and effects of these genetic factors are not fully understood. It discusses polymorphisms in genes related to inflammation and androgen biosynthesis, such as MUC1, TNF-α, IL-1α, androgen receptor VNTR, and CYP1A1, noting that these may contribute to acne development, although findings are inconsistent across different populations. The document also mentions the IL-1A +4,845 SNP and the CYP17 -34T>C promoter polymorphism, which are associated with acne severity, and the potential role of FGFR2 mutations. It emphasizes the complexity of acne pathogenesis, the influence of environmental factors and lifestyle, and the need for more comprehensive genetic studies to fully elucidate the molecular mechanisms involved in acne.
200 citations,
August 2009 in “Experimental dermatology” Eating high-glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.
466 citations,
June 2009 in “Experimental dermatology” We now understand more about what causes acne and this could lead to better, more personalized treatments.
63 citations,
May 2009 in “Dermato-endocrinology” Increased FGFR2b signaling, influenced by androgens, plays a role in causing acne.
96 citations,
September 2008 in “Seminars in Cutaneous Medicine and Surgery” Hormonal treatments, including birth control and antiandrogens, can effectively treat acne in women.
209 citations,
September 2008 in “Dermatologic Therapy” Androgens can both increase and decrease hair growth in different parts of the body.
305 citations,
February 2007 in “Hormone and metabolic research” Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.
186 citations,
July 1998 in “Journal of Cutaneous Medicine and Surgery” Shorter CAG repeats may cause hair and skin issues, while longer ones may link to acne.
76 citations,
January 2007 in “American Journal of Clinical Dermatology” Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.
29 citations,
February 2018 in “Genetics research international” Certain genetic variations are linked to increased androgen levels in PCOS, but more research is needed to understand these connections fully.
1 citations,
October 2010 in “Cambridge University Press eBooks” Hormonal therapies are effective for managing hair and skin symptoms in women with PCOS.
27 citations,
December 2015 in “Mayo Clinic Proceedings” The document concludes that lifestyle changes and medical treatments can significantly reduce symptoms of Hidradenitis Suppurativa, a chronic skin condition.
69 citations,
November 2010 in “Middle East Fertility Society Journal” PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.
