TLDR The document concludes that lifestyle changes and medical treatments can significantly reduce symptoms of Hidradenitis Suppurativa, a chronic skin condition.
The document from December 2015 provides a comprehensive overview of Hidradenitis Suppurativa (HS), a chronic inflammatory skin condition, emphasizing its significant impact on patients' quality of life. It highlights the disease's prevalence, estimated between 0.1% and 4.1%, and its onset typically after puberty, with a higher incidence in females. The pathogenesis of HS is not fully understood but is thought to involve immunologic factors, genetic predisposition, obesity, and smoking. The document outlines an evidence-based management algorithm for HS, recommending lifestyle modifications such as smoking cessation and weight loss, which can lead to a 35% decrease in symptoms. Various medical treatments are discussed, including antibiotics, hormonal therapies, and biologics like TNF inhibitors, with infliximab showing an 80-89% response rate. Surgical intervention is advised for improved outcomes, and a maintenance regimen of topical clindamycin is recommended for all patients. The document also notes the association of HS with metabolic syndrome and insulin resistance and calls for more research to evaluate treatment effectiveness and understand the disease better.
62 citations,
March 2013 in “JAMA Dermatology” Finasteride reduces Hidradenitis Suppurativa flare-ups in children and teens, but long-term safety is unknown.
73 citations,
December 2010 in “Current opinion in infectious diseases/Current opinion in infectious diseases, with evaluated MEDLINE” Hidradenitis suppurativa is a skin condition possibly caused by hair follicle issues, with treatments focusing on infection and inflammation.
405 citations,
May 2007 in “Journal of The American Academy of Dermatology” Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.
99 citations,
April 2005 in “Journal of Dermatological Treatment” Finasteride effectively treats hidradenitis suppurativa for most patients.
238 citations,
July 2003 in “British Journal of Plastic Surgery” Hidradenitis suppurativa, a chronic skin disease, can be managed with antibiotics, lifestyle changes, and in severe cases, surgery. Early diagnosis and careful planning are key, and laser treatment can be an efficient solution for mild to severe cases.
50 citations,
December 1999 in “British Journal of Dermatology” Finasteride improves hidradenitis suppurativa but not for child-bearing women.
68 citations,
May 1991 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Both cyproterone acetate and spironolactone effectively reduce hair growth in women with hirsutism.
59 citations,
June 2022 in “Frontiers in medicine” There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.
March 2024 in “Current issues in molecular biology” Personalized medicine in dermatology uses molecular biomarkers to improve diagnosis and treatment but needs further advancements for practical use.
January 2017 in “Springer eBooks” The document explains various skin conditions and their treatments.
52 citations,
February 2018 in “Diabetology & Metabolic Syndrome” Some skin conditions may indicate metabolic syndrome, which could help with early detection and management of related health issues.
208 citations,
July 2001 in “Journal of The American Academy of Dermatology” Pregnancy can cause various skin changes and diseases, with PUPPP being the most common skin condition specific to pregnancy.
