Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes
February 2001
in “
The journal of investigative dermatology/Journal of investigative dermatology
”
TLDR Interleukin-1 increases keratin K6 production in skin cells.
The study demonstrated that interleukin-1 (IL-1) induced the transcription of keratin K6 in human epidermal keratinocytes, leading to increased K6 protein and mRNA levels. This effect was specific to IL-1 and was mediated through the C/EBPβ transcription factor. The induction was time and concentration dependent, occurring only in confluent keratinocytes, and was enhanced by epidermal growth factor or tumor necrosis factor-α. The study used various experimental techniques, including transfection of HeLa cells and electrophoretic mobility shift assays, to confirm these findings. The results suggested that IL-1 plays a significant role in cutaneous inflammation and wound healing by regulating keratin gene expression.
