TLDR Innate immunity genes in hair follicle stem cells might have new roles beyond traditional immune functions.
The document explored the role of innate immunity in the regulation and mobilization of keratinocyte stem cells (KSCs), particularly focusing on the expression of Toll-like receptors (Tlrs) and cytokines. It suggested that these immune components might influence the activation, proliferation, and differentiation of KSCs, similar to their role in hematopoietic and mesenchymal stem cells. The study proposed that innate immunity could be crucial for the self-renewal and migratory behavior of KSCs, with implications for skin regeneration, wound healing, and autoimmune conditions like alopecia areata. The findings indicated a potential overlap between immune responses and skin regeneration processes, suggesting that immune mechanisms might be harnessed for therapeutic strategies in skin repair and regeneration.
61 citations,
September 2010 in “Journal of Dermatological Science” Stress hormones and autoimmune reactions can cause hair loss.
717 citations,
June 2010 in “Nature” Alopecia areata involves both innate and adaptive immunity, with specific genes linked to the disease.
90 citations,
February 2001 in “The journal of investigative dermatology/Journal of investigative dermatology” Interleukin-1 increases keratin K6 production in skin cells.
1010 citations,
August 2000 in “Cell” Hair follicle stem cells can form both hair follicles and skin.
8 citations,
July 2022 in “International Journal of Molecular Sciences” Skin cells release substances important for healing and fighting infection, and understanding these could improve skin disorder treatments.
57 citations,
March 2019 in “Immunity” The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.
252 citations,
April 2009 in “Seminars in Cell & Developmental Biology” The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.
2 citations,
January 2017 in “AIMS cell and tissue engineering” Mesenchymal stem cells show promise for treating various skin conditions and may help regenerate hair.
773 citations,
August 2017 in “International Journal of Molecular Sciences” The secretions of mesenchymal stem cells could be used for healing without using the cells themselves.
