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GlossaryKeratinocyte Stem Cells (KSCs)

specialized skin cells that regenerate and form keratinocytes

Keratinocyte Stem Cells (KSCs) are specialized cells found in the basal layer of the epidermis, the outermost layer of the skin. These cells have the unique ability to self-renew and differentiate into keratinocytes, which are the primary cells that make up the skin, hair, and nails. KSCs play a crucial role in skin regeneration and wound healing, making them essential for maintaining healthy skin and repairing damage.

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research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

550 citations, December 2005 in “The Journal of clinical investigation/The journal of clinical investigation”

Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.

research Targeted Disruption of Stat3 Reveals a Major Role for Follicular Stem Cells in Skin Tumor Initiation

49 citations, October 2009 in “Cancer research”

Disrupting Stat3 in hair follicle stem cells greatly reduces skin tumor formation.

research Keratinocyte Stem Cells but Not Melanocyte Stem Cells Are the Primary Target for Radiation-Induced Hair Graying

30 citations, April 2013 in “Journal of Investigative Dermatology”

Radiation mainly affects keratinocyte stem cells, not melanocyte stem cells, causing hair to gray.

research Hair-Growth-Promoting Effect of Conditioned Medium of High Integrin α6 and Low CD71 Positive Keratinocyte Cells

17 citations, February 2015 in “International Journal of Molecular Sciences”

A special mix from certain skin cells can help hair grow by making hair root cells grow faster and activating growth signals.

research Innate Immunity and the Regulation and Mobilization of Keratinocyte Stem Cells: Are the Old Players Playing a New Game?

11 citations, July 2012 in “Experimental dermatology”

Innate immunity genes in hair follicle stem cells might have new roles beyond traditional immune functions.

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