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GlossaryLymphoepithelial Kazal-type-related Inhibitor

protein regulating skin and hair enzyme activity

Lymphoepithelial Kazal-type-related Inhibitor (LEKTI) is a protein that plays a crucial role in regulating the activity of certain enzymes involved in skin and hair health. It acts as a serine protease inhibitor, helping to maintain the integrity of the skin barrier and prevent excessive inflammation. Mutations in the gene encoding LEKTI can lead to skin disorders such as Netherton syndrome, which is characterized by red, scaly skin and hair abnormalities.

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Advances in Hair Diseases

research Advances in Hair Diseases

5 citations, November 2008 in “Advances in Dermatology”

The review highlights the importance of stem cells in hair health and suggests new treatment strategies for hair loss conditions.

Structure and Development of the Skin and Cutaneous Appendages

research Structure and Development of the Skin and Cutaneous Appendages

1 citations, July 2016 in “Elsevier eBooks”

Understanding skin structure and development helps diagnose and treat skin disorders.

Hair Microscopy: An Easy Adjunct to Diagnosis of Systemic Diseases in Children

research Hair Microscopy: An Easy Adjunct to Diagnosis of Systemic Diseases in Children

3 citations, November 2021 in “Applied Microscopy”

Hair microscopy is a simple and cost-effective method to help diagnose systemic diseases in children.

Severe Hypernatremia as Presentation of Netherton Syndrome

research Severe Hypernatremia as Presentation of Netherton Syndrome

November 2023 in “Global Medical Genetics”

Netherton syndrome can cause severe dehydration, infections, and growth issues in infants.

Cushing Syndrome from Percutaneous Absorption of 1% Hydrocortisone Ointment in Netherton Syndrome

research Cushing Syndrome from Percutaneous Absorption of 1% Hydrocortisone Ointment in Netherton Syndrome

42 citations, January 2007 in “Pediatric dermatology”

Low-potency steroids can cause serious side effects in people with skin conditions like Netherton syndrome.

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