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GlossaryLymphoepithelial Kazal-type-related Inhibitor

protein regulating skin and hair enzyme activity

Lymphoepithelial Kazal-type-related Inhibitor (LEKTI) is a protein that plays a crucial role in regulating the activity of certain enzymes involved in skin and hair health. It acts as a serine protease inhibitor, helping to maintain the integrity of the skin barrier and prevent excessive inflammation. Mutations in the gene encoding LEKTI can lead to skin disorders such as Netherton syndrome, which is characterized by red, scaly skin and hair abnormalities.

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research Lekti: Netherton Syndrome And Atopic Dermatitis

1 citations , February 2013 in “InTech eBooks”

LEKTI is crucial for skin barrier and immune function, affecting conditions like Netherton syndrome and atopic dermatitis.

research Netherton Syndrome

November 2019 in “Harper's Textbook of Pediatric Dermatology”

Netherton syndrome is a genetic skin disorder causing severe skin issues and requires careful treatment to protect the skin barrier.

Severe Hypernatremia as Presentation of Netherton Syndrome

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