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GlossaryLymphoepithelial Kazal-type-related Inhibitor

protein regulating skin and hair enzyme activity

Lymphoepithelial Kazal-type-related Inhibitor (LEKTI) is a protein that plays a crucial role in regulating the activity of certain enzymes involved in skin and hair health. It acts as a serine protease inhibitor, helping to maintain the integrity of the skin barrier and prevent excessive inflammation. Mutations in the gene encoding LEKTI can lead to skin disorders such as Netherton syndrome, which is characterized by red, scaly skin and hair abnormalities.

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research Advances in Hair Diseases

5 citations , November 2008 in “Advances in Dermatology”

The review highlights the importance of stem cells in hair health and suggests new treatment strategies for hair loss conditions.

research Structure and Development of the Skin and Cutaneous Appendages

1 citations , July 2016 in “Elsevier eBooks”

Understanding skin structure and development helps diagnose and treat skin disorders.

research Lekti: Netherton Syndrome And Atopic Dermatitis

1 citations , February 2013 in “InTech eBooks”

LEKTI is crucial for skin barrier and immune function, affecting conditions like Netherton syndrome and atopic dermatitis.

research Netherton Syndrome

November 2019 in “Harper's Textbook of Pediatric Dermatology”

Netherton syndrome is a genetic skin disorder causing severe skin issues and requires careful treatment to protect the skin barrier.

research Hair Microscopy: An Easy Adjunct to Diagnosis of Systemic Diseases in Children

3 citations , November 2021 in “Applied Microscopy”

Hair microscopy is a simple and cost-effective method to help diagnose systemic diseases in children.

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