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    Glossary Lymphoepithelial Kazal-type-related Inhibitor

    protein regulating skin and hair enzyme activity

    Lymphoepithelial Kazal-type-related Inhibitor (LEKTI) is a protein that plays a crucial role in regulating the activity of certain enzymes involved in skin and hair health. It acts as a serine protease inhibitor, helping to maintain the integrity of the skin barrier and prevent excessive inflammation. Mutations in the gene encoding LEKTI can lead to skin disorders such as Netherton syndrome, which is characterized by red, scaly skin and hair abnormalities.

    Research 10 of 50

    1. JAK-Inhibitors Beyond the Label: Emerging Applications in Dermatology Medicina · 2026
    2. Netherton syndrome subtypes share IL-17/IL-36 signature with distinct IFN-α and allergic responses Journal of Allergy and Clinical Immunology · 2021 · 59 citations
    3. Advances in Hair Diseases Advances in Dermatology · 2008 · 5 citations
    4. LB1007 Systemic treatment with a KLK5 inhibitor shows efficacy in a murine model of Netherton syndrome Journal of Investigative Dermatology · 2024
    5. 267 Single- and multiple-ascending dose studies of DS-2325a, a KLK5 inhibitor for the treatment of Netherton syndrome Journal of Investigative Dermatology · 2024
    6. The PDE4 inhibitor, apremilast, suppresses experimentally induced alopecia areata in human skin in vivo Journal of Dermatological Science · 2014 · 52 citations
    7. LEKTI: Netherton Syndrome and Atopic Dermatitis InTech eBooks · 2013 · 1 citations
    8. Netherton Syndrome Harper's Textbook of Pediatric Dermatology · 2019
    9. New developments in the molecular treatment of ichthyosis: review of the literature Orphanet journal of rare diseases · 2022 · 21 citations
    10. Protease activity, localization and inhibition in the human hair follicle International Journal of Cosmetic Science · 2013 · 11 citations
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