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    Glossary TYK2 Inhibitor

    blocks enzyme activity to reduce inflammation in autoimmune diseases

    A TYK2 inhibitor is a type of medication that blocks the activity of the TYK2 enzyme, which is involved in the immune system's signaling pathways. By inhibiting this enzyme, these drugs can help reduce inflammation and are being researched for treating autoimmune diseases like psoriasis and alopecia areata.

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    Research 10 of 229

    1. JAK 1-3 inhibitors and TYK-2 inhibitors in dermatology: Practical pearls for the primary care physician Journal of Family Medicine and Primary Care · 2024 · 6 citations
    2. 544 Alopecia areata lesions show significant changes in immune and keratin biomarkers that correlate with clinical improvement with oral Janus kinase inhibitors PF-06651600 (JAK3) and PF-06700841 (TYK2/JAK1) Journal of Investigative Dermatology · 2019 · 5 citations
    3. 265 Modulation of disease-central cytokine pathways with TAK-279, a highly selective oral tyrosine kinase 2 (TYK2) inhibitor, defines clinical response in patients with psoriasis Journal of Investigative Dermatology · 2024 · 1 citations
    4. Innovative Therapeutic Strategies in TYK2-Targeted Treatments: From Cancer to Autoimmune Disorders ACS Medicinal Chemistry Letters · 2024 · 1 citations
    5. TYK2 Inhibition with Deucravacitinib Improves Clinical Outcomes and Resolves Interferon-Driven Inflammation in Lichen Planopilaris 2026
    6. A review of Janus kinase inhibitor use in scarring alopecia JAAD reviews. · 2025 · 4 citations
    7. Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, in patients with alopecia areata: efficacy and safety results of a phase II, multicenter, randomized, double-blinded, placebo-controlled trial British Journal of Dermatology · 2026
    8. Complete hair regrowth in a patient with severe alopecia areata treated with deucravacitinib Clinical and Experimental Dermatology · 2025 · 1 citations
    9. Rapid hair regrowth in an alopecia universalis patient with deucravacitinib: A case report SAGE open medical case reports · 2023 · 1 citations
    10. Deucravacitinib in dermatology: current indication and existing off-label data Drugs in Context · 2026
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