Search
for

    Glossary Lymphoepithelial Kazal-type-related Inhibitor

    protein regulating skin and hair enzyme activity

    Lymphoepithelial Kazal-type-related Inhibitor (LEKTI) is a protein that plays a crucial role in regulating the activity of certain enzymes involved in skin and hair health. It acts as a serine protease inhibitor, helping to maintain the integrity of the skin barrier and prevent excessive inflammation. Mutations in the gene encoding LEKTI can lead to skin disorders such as Netherton syndrome, which is characterized by red, scaly skin and hair abnormalities.

    Sort by

    Research 30 of 50

    1. JAK-Inhibitors Beyond the Label: Emerging Applications in Dermatology Medicina · 2026
    2. Netherton syndrome subtypes share IL-17/IL-36 signature with distinct IFN-α and allergic responses Journal of Allergy and Clinical Immunology · 2021 · 59 citations
    3. Advances in Hair Diseases Advances in Dermatology · 2008 · 5 citations
    4. LB1007 Systemic treatment with a KLK5 inhibitor shows efficacy in a murine model of Netherton syndrome Journal of Investigative Dermatology · 2024
    5. 267 Single- and multiple-ascending dose studies of DS-2325a, a KLK5 inhibitor for the treatment of Netherton syndrome Journal of Investigative Dermatology · 2024
    6. The PDE4 inhibitor, apremilast, suppresses experimentally induced alopecia areata in human skin in vivo Journal of Dermatological Science · 2014 · 52 citations
    7. LEKTI: Netherton Syndrome and Atopic Dermatitis InTech eBooks · 2013 · 1 citations
    8. Netherton Syndrome Harper's Textbook of Pediatric Dermatology · 2019
    9. New developments in the molecular treatment of ichthyosis: review of the literature Orphanet journal of rare diseases · 2022 · 21 citations
    10. Protease activity, localization and inhibition in the human hair follicle International Journal of Cosmetic Science · 2013 · 11 citations
    11. Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions International journal of molecular sciences · 2023 · 2 citations
    12. A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective International Journal of Molecular Sciences · 2022 · 8 citations
    13. Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production Journal of Investigative Dermatology · 2019 · 40 citations
    14. Hair microscopy: an easy adjunct to diagnosis of systemic diseases in children Applied Microscopy · 2021 · 3 citations
    15. Construction of transcriptome atlas of white yak hair follicle during anagen and catagen using single-cell RNA sequencing BMC Genomics · 2022 · 8 citations
    16. Severe Hypernatremia as Presentation of Netherton Syndrome Global Medical Genetics · 2023
    17. Dupilumab in a 9-week-old with Netherton Syndrome Leads to Deep Symptom Control Journal of Clinical Immunology · 2024 · 5 citations
    18. Cushing Syndrome from Percutaneous Absorption of 1% Hydrocortisone Ointment in Netherton Syndrome Pediatric dermatology · 2007 · 42 citations
    19. Netherton Syndrome in a 9-Month-Old Child: Unraveling a Complex Dermatologic Disorder OBM Genetics · 2025
    20. Evolving approaches to profiling the microbiome in skin disease Frontiers in immunology · 2023 · 9 citations
    21. KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype PLoS Genetics · 2017 · 87 citations
    22. Congenital hair loss disorders: Rare, but not too rare The Journal of Dermatology · 2011 · 41 citations
    23. Ichthyosis in Unani Medicine: A Comprehensive Review of Disorders of Cornification and their Modern Dermatological Correlates International Journal of Science and Research (IJSR) · 2026
    24. Light microscopy of the hair: A simple tool to "untangle" hair disorders International Journal of Trichology · 2011 · 24 citations
    25. Early skin biopsy is helpful for the diagnosis and management of neonatal and infantile erythrodermas 2010
    26. 565 Cutaneous delivery of LEKTI via an engineered strain of staphylococcus epidermidis for the treatment of netherton syndrome Journal of Investigative Dermatology · 2024
    27. Forme létale de syndrome de Netherton au sein d’une famille multiplex consanguine Archives de Pédiatrie · 2011 · 5 citations
    28. Netherton Syndrome With Trichorrhexis Invaginata “Bamboo Hair” Under Dermoscopy: Case Images Clinical Case Reports · 2025
    29. Ichthyosis linearis circumflexa in a child. Response to narrowband UVB therapy. Journal of Dermatological Case Reports · 2015 · 9 citations
    30. Netherton Syndrome Associated with Growth Hormone Deficiency Pediatric Dermatology · 2013 · 21 citations