Cushing Syndrome from Percutaneous Absorption of 1% Hydrocortisone Ointment in Netherton Syndrome

    January 2007 in “ Pediatric dermatology ”
    Caroline Halverstam, Akshaya Vachharajani, Susan B. Mallory
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    TLDR Low-potency steroids can cause serious side effects in people with skin conditions like Netherton syndrome.
    An 11-year-old boy with Netherton syndrome (NS) developed Cushing syndrome after using 1% hydrocortisone ointment extensively over his entire body for more than a year. NS is characterized by defective skin barrier function, leading to increased absorption of topical medications. Despite being a low-potency steroid, the hydrocortisone ointment caused significant systemic side effects due to the compromised skin barrier in NS. This case highlighted the need for cautious use of even low-potency steroids in patients with NS and other conditions with reduced skin barrier function, emphasizing the importance of monitoring and educating patients and caregivers on safe usage.
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