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    Glossary Membrane-bound transcription factor site-2 protease

    enzyme that activates proteins by cutting them in membranes

    Membrane-bound transcription factor site-2 protease (S2P) is an enzyme that plays a crucial role in activating certain proteins by cutting them at specific sites within the cell membrane. This process is essential for regulating various cellular functions, including stress responses and cholesterol metabolism. For professionals, S2P is known for its role in the regulated intramembrane proteolysis (RIP) pathway, which is critical for the activation of sterol regulatory element-binding proteins (SREBPs).

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    1. Two novel MBTPS2 missense mutations impairing S2P proteolytic activity lead to IFAP syndrome with new phenotypic anomalies Journal of dermatological science · 2023
    2. Targeting host cell proteases as a potential treatment strategy to limit the spread of SARS‐CoV‐2 in the respiratory tract Pharmacology Research & Perspectives · 2020 · 15 citations
    3. Androgen sensitivity gateway to COVID‐19 disease severity Drug Development Research · 2020 · 123 citations
    4. TMPRSS2: A Key Host Factor in SARS-CoV-2 Infection and Potential Therapeutic Target Medeniyet Medical Journal · 2025 · 4 citations
    5. Recurrent MBTPS2 variant c.970+5G>A in IFAP syndrome: a mutational hotspot Human Genome Variation · 2026
    6. The Tissue-dependent Keratin 19 Gene Transcription Is Regulated by GKLF/KLF4 and Sp1 Journal of Biological Chemistry · 2000 · 119 citations
    7. Intramembrane Proteolysis of Astrotactins Journal of Biological Chemistry · 2017 · 8 citations
    8. IL-36γ drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes 2019 · 32 citations
    9. All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration Stem cell biology and regenerative medicine · 2018
    10. Delineation of Matriptase Protein Expression by Enzymatic Gene Trapping Suggests Diverging Roles in Barrier Function, Hair Formation, and Squamous Cell Carcinogenesis American Journal Of Pathology · 2006 · 100 citations
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