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    GlossaryMembrane-bound transcription factor site-2 protease

    enzyme that activates proteins by cutting them in membranes

    Membrane-bound transcription factor site-2 protease (S2P) is an enzyme that plays a crucial role in activating certain proteins by cutting them at specific sites within the cell membrane. This process is essential for regulating various cellular functions, including stress responses and cholesterol metabolism. For professionals, S2P is known for its role in the regulated intramembrane proteolysis (RIP) pathway, which is critical for the activation of sterol regulatory element-binding proteins (SREBPs).

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