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    Glossary Membrane-bound transcription factor site-2 protease

    enzyme that activates proteins by cutting them in membranes

    Membrane-bound transcription factor site-2 protease (S2P) is an enzyme that plays a crucial role in activating certain proteins by cutting them at specific sites within the cell membrane. This process is essential for regulating various cellular functions, including stress responses and cholesterol metabolism. For professionals, S2P is known for its role in the regulated intramembrane proteolysis (RIP) pathway, which is critical for the activation of sterol regulatory element-binding proteins (SREBPs).

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    1. Two novel MBTPS2 missense mutations impairing S2P proteolytic activity lead to IFAP syndrome with new phenotypic anomalies Journal of dermatological science · 2023
    2. Targeting host cell proteases as a potential treatment strategy to limit the spread of SARS‐CoV‐2 in the respiratory tract Pharmacology Research & Perspectives · 2020 · 15 citations
    3. Androgen sensitivity gateway to COVID‐19 disease severity Drug Development Research · 2020 · 123 citations
    4. TMPRSS2: A Key Host Factor in SARS-CoV-2 Infection and Potential Therapeutic Target Medeniyet Medical Journal · 2025 · 4 citations
    5. Recurrent MBTPS2 variant c.970+5G>A in IFAP syndrome: a mutational hotspot Human Genome Variation · 2026
    6. The Tissue-dependent Keratin 19 Gene Transcription Is Regulated by GKLF/KLF4 and Sp1 Journal of Biological Chemistry · 2000 · 119 citations
    7. Intramembrane Proteolysis of Astrotactins Journal of Biological Chemistry · 2017 · 8 citations
    8. IL-36γ drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes 2019 · 32 citations
    9. All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration Stem cell biology and regenerative medicine · 2018
    10. Delineation of Matriptase Protein Expression by Enzymatic Gene Trapping Suggests Diverging Roles in Barrier Function, Hair Formation, and Squamous Cell Carcinogenesis American Journal Of Pathology · 2006 · 100 citations
    11. The Genomic Variation in Textured Hair: Implications in Developing a Holistic Hair Care Routine Cosmetics · 2024
    12. SPT6 maintains epidermal homeostasis by inhibiting an NF-κB-positive feedback loop to prevent excessive inflammation Cellular and Molecular Immunology · 2026
    13. The Harmonies Played by TGF-β in Stem Cell Biology Cell Stem Cell · 2012 · 156 citations
    14. Langerin+ Dendritic Cells in Cutaneous Fibrosis: The TGF-β1 Signaling Axis Clinical Cosmetic and Investigational Dermatology · 2025
    15. The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates Nature cell biology · 2023 · 6 citations
    16. Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity 2023
    17. Functional mapping of the mouse <i>hairless</i> gene promoter region bioRxiv (Cold Spring Harbor Laboratory) · 2018
    18. Mutations in SREBF1, Encoding Sterol Regulatory Element Binding Transcription Factor 1, Cause Autosomal-Dominant IFAP Syndrome American journal of human genetics · 2020 · 34 citations
    19. From bedside to bench: regulation of host factors in SARS-CoV-2 infection Experimental and Molecular Medicine · 2021 · 4 citations
    20. Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation Differentiation · 2009 · 35 citations
    21. Transcription Factor DLX5 Promotes Hair Follicle Stem Cell Differentiation by Regulating the c-MYC/microRNA-29c-3p/NSD1 Axis Frontiers in Cell and Developmental Biology · 2021 · 4 citations
    22. The secret identities of TMPRSS2: Fertility factor, virus trafficker, inflammation moderator, prostate protector and tumor suppressor Tumor Biology · 2021 · 16 citations
    23. Polyamine Oxidase Expression Is Downregulated by 17β-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells International Journal of Molecular Sciences · 2022 · 8 citations
    24. Cardiac and Renal SARS-CoV-2 Viral Entry Protein Regulation by Androgens and Diet: Implications for Polycystic Ovary Syndrome and COVID-19 International Journal of Molecular Sciences · 2021 · 3 citations
    25. Fatal autoimmunity results from the conditional deletion of Snai2 and Snai3 Cellular immunology · 2015 · 8 citations
    26. PAK4 signaling in health and disease: defining the PAK4–CREB axis Experimental & Molecular Medicine · 2019 · 81 citations
    27. Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02 Nature Communications · 2019 · 115 citations
    28. A case of <i>MBTPS1</i>‐related disorder due to compound heterozygous variants in <i>MBTPS1</i> gene: Genotype–phenotype expansion and the emergence of a novel syndrome American journal of medical genetics. Part A · 2023
    29. Recombinant Oil-Body-Expressed Oleosin-hFGF5 in Arabidopsis thaliana Regulates Hair Growth Genes · 2022 · 1 citations
    30. Expression of Signaling Components in Embryonic Eyelid Epithelium PloS one · 2014 · 5 citations