TLDR Mice with enhanced regeneration abilities may help develop new regenerative medicine therapies.
The document from 2017 explores the regenerative abilities of the Murphy Roths Large (MRL) mouse, which can regenerate tissues similarly to amphibians, and the role of prolyl hydroxylase domain proteins (PHDs) and hypoxia-inducible factor (HIF)-1α in this process. The MRL mouse uses aerobic glycolysis for its metabolism, which supports cell proliferation and is linked to regeneration. The study found that MRL mice have increased levels of HIF-1α and inflammation, which are crucial for tissue regeneration. It also observed that PHD inhibitors, which are already in clinical use for other conditions, could potentially be used to induce regenerative healing in mammals. The document suggests that further understanding of PHD pathways and their inhibitors could lead to new regenerative medicine therapies. Additionally, it raises questions about the optimal use of PHD inhibitors for tissue regeneration, including the desired levels of HIF1, potential side effects, and the best methods for drug delivery. The research was supported by the National Institutes of Health.
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January 2012 in “Current Topics in Microbiology and Immunology” Mice that can regenerate tissue have cells that pause in the cell cycle, which is important for healing, similar to axolotls.
20 citations
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September 2010 in “Cell Cycle” Mice can regenerate ear tissue without the p53 protein.
October 2025 in “Gene Expression” Exosome therapy could be a promising new way to treat hair loss.
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October 2020 in “Pharmaceutics” The document reviewed the use of biopolymeric electrospun nanofibers (eNFs) based on polysaccharides for wound healing management. These nanofibers were noted for their ability to mimic the extracellular matrix, promoting cell adhesion and proliferation, and their porous nature allowing nutrient exchange and preventing bacterial contamination. Polysaccharides like chitosan, alginate, and cellulose were highlighted for their biocompatibility, biodegradability, and potential antimicrobial properties. The review emphasized the advantages of eNFs over traditional dressings, such as maintaining a moist environment and allowing gas exchange. Various studies demonstrated the effectiveness of these eNFs in promoting wound healing, reducing inflammation, and providing antibacterial effects, with specific formulations showing promising results in in vivo studies. The document also discussed the challenges in transitioning from laboratory to clinical applications and the need for multidisciplinary collaboration to address limitations in current wound dressings.
March 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” Removing a specific gene in certain skin cells causes hair loss on the body by disrupting normal hair development.
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July 2022 in “British Journal of Dermatology” Targeting specific genes in certain pathways may help treat male pattern baldness.
22 citations
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December 2017 in “International Journal of Molecular Sciences” Minoxidil boosts hair growth by increasing blood flow and nutrients to hair follicles.
