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research Oxygen, Metabolism, and Regeneration: Lessons from Mice

35 citations , October 2017 in “Trends in Molecular Medicine”

This research suggests that targeting the HIF-1α pathway via PHD inhibitors may enable regeneration similar to amphibians in mammals, potentially fast-tracking regenerative therapies from mice to humans.

research Topical Janus kinase inhibitors: A review of applications in dermatology

63 citations , April 2018 in “Journal of the American Academy of Dermatology”

This review discusses the efficacy and safety of topical JAK inhibitors for inflammatory skin conditions, reporting modest benefits in psoriasis and atopic dermatitis but mixed results for vitiligo and inconclusive data for alopecia areata.

research Janus Kinase Inhibitors for Alopecia Areata

12 citations , June 2023 in “JAMA network open”

In this study of seven randomized clinical trials, JAK inhibitors were associated with improved hair regrowth outcomes in alopecia areata patients compared to placebo, with oral administration being more effective than external application, though longer trials are needed to confirm safety and effectiveness.

At The Crossroads Of Two Alopecias: Androgenetic Alopecia Pattern Of Hair Regrowth In Patients With Alopecia Areata Treated With Oral Janus Kinase Inhibitors

research At the crossroads of 2 alopecias: Androgenetic alopecia pattern of hair regrowth in patients with alopecia areata treated with oral Janus kinase inhibitors

4 citations , April 2020 in “JAAD case reports”

This article discusses the autoimmune causes of alopecia areata and reports no new clinical results.

research Melanotic pigmentation in excisional scar of melanoma patient who received BRAF and MEK inhibitors

1 citations , August 2018 in “Journal of The American Academy of Dermatology”

Patients with melanoma who saw dermatologists and were from higher-income areas were more likely to have follow-up visits, which was linked to lower mortality.

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community Androsterone as a Neurosteroid Replacement Strategy for 5α-Reductase Inhibitor–Associated Sexual and Affective Dysfunction

in Research/Science 36 upvotes 2 months ago

Androsterone may help with sexual and affective dysfunction from finasteride by replacing disrupted neurosteroids without increasing androgenic side effects. Controlled testing is needed to confirm its effectiveness and safety.

community BREAKTHROUGH: I’m a radiochemist and discovered a radioactive isotope scalp serum that OUTPERFORMS Minoxidil and 5-AR inhibitors! (Lab Data Inside)

in Satire 1 year ago

A satirical post where someone claims to have developed a radioactive isotope scalp serum using Polonium-210 that outperforms Minoxidil and finasteride for hair regrowth. The serum reportedly stimulates DNA repair in hair follicles, leading to significant hair density increase, but the post is met with skepticism and concerns about safety.

community Will PP405 render Minox and Fin obsolete?

30 upvotes 1 year ago

PP405 might make minoxidil unnecessary, but finasteride or other 5AR inhibitors may still be needed. PP405 is expected to be expensive and not available until at least 2028, with limited information on its effectiveness.

community Breezula is the final brick in the wall

36 upvotes 2 months ago

Breezula is discussed as a potential topical anti-androgen treatment for hair loss, with mixed opinions on its effectiveness and side effects compared to other treatments like finasteride, minoxidil, and RU58841. Some users express skepticism about its long-term efficacy and potential side effects, while others are hopeful for its approval and use in combination with existing treatments.

community The mechanism of androgenic alopecia

36 upvotes 11 months ago

DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

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