A Rare Case of Keratosis Follicularis Spinulosa Decalvans Affecting a Female Child

    January 2022 in “ Clinical dermatology review ”
    Varsha Sakleshpur Prasad, Rashmi Laxman Chavan, Sir Sanjay Ramachandra Tjejaswi, Jayashree Basavaraju, Chandramohan Kudligi, Pradeep Vittal Bhagwat
    TLDR A girl with a rare skin condition called Keratosis Follicularis Spinulosa Decalvans showed no significant improvement with treatment.
    A 10-year-old girl with keratosis follicularis spinulosa decalvans (KFSD) presented with congenital alopecia and generalized rough skin. Examination revealed follicular papules, scarring alopecia, and xerosis. Histopathology confirmed KFSD, a rare condition often affecting males, linked to Xp22 mutations affecting cholesterol and lipid homeostasis. Despite treatment with topical clobetasol, no significant improvement was observed. KFSD's prognosis involves progressive follicular obliteration, and treatments, including corticosteroids and retinoids, have shown limited success. This case is notable for its rarity, especially in females, who typically exhibit milder symptoms.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 19 results

      community Hair Loss Inflammation Prevention Stack

      in Research/Science  49 upvotes 3 months ago
      The conversation discusses a hair loss and scalp care routine involving ciclopirox shampoo, benzoyl peroxide, clindamycin gel, clobetasol propionate, and calcipotriol to manage seborrheic dermatitis, folliculitis, and inflammation. It also touches on the role of diet and other treatments like oral minoxidil and pioglitazone for scalp health.

      community My skin is always dry and flakes like chalk (25)

      in Transgender  6 upvotes 1 year ago
      The user underwent a biopsy two years ago and was diagnosed with keratosis pilaris, leading to hair issues. They tried treatments including Minoxidil, betamethasone, lymecycline, topical Accutane, and dutasteride, as well as diet changes, without improvement in hair thickness or skin dryness.

      community Is Finasteride helping with my skin tags or is it something else?

      in Treatment  3 upvotes 5 months ago
      The user noticed improvement in skin tags after using oral and topical finasteride and minoxidil, along with other supplements like thiamine, P5P, serrapeptase, nattokinase, and retinol. They are unsure which treatment caused the improvement and are seeking input on whether finasteride's DHT reduction could be responsible.

      community What are these spots on my scalp

      in Treatment  51 upvotes 1 year ago
      A user noticed non-itchy, non-bleeding spots on their scalp while experiencing hair loss. Replies suggest the spots are likely sunspots or liver spots and recommend seeing a dermatologist; hair loss is attributed to male pattern baldness.

      community My Experience and a Discourse on "DUPA"

      in Treatment  10 upvotes 1 year ago
      The user discusses their hair loss experience, exploring various hypotheses including thyroid levels, vitamin D, DHEA, nutritional deficiency, diabetes, seborrheic dermatitis, lack of nutrition to hair follicles, chronic inflammation, female pattern hair loss causes, cortisol, and prolactin levels. They are currently using finasteride, beta-sitosterol, and have tried topical dutasteride and microneedling therapy.

    Related Research

    5 / 5 results