A Rare Case of Keratosis Follicularis Spinulosa Decalvans Affecting a Female Child

    January 2022 in “ Clinical dermatology review ”
    Varsha Sakleshpur Prasad, Rashmi Laxman Chavan, Sir Sanjay Ramachandra Tjejaswi, Jayashree Basavaraju, Chandramohan Kudligi, Pradeep Vittal Bhagwat
    TLDR A girl with a rare skin condition called Keratosis Follicularis Spinulosa Decalvans showed no significant improvement with treatment.
    A 10-year-old girl with keratosis follicularis spinulosa decalvans (KFSD) presented with congenital alopecia and generalized rough skin. Examination revealed follicular papules, scarring alopecia, and xerosis. Histopathology confirmed KFSD, a rare condition often affecting males, linked to Xp22 mutations affecting cholesterol and lipid homeostasis. Despite treatment with topical clobetasol, no significant improvement was observed. KFSD's prognosis involves progressive follicular obliteration, and treatments, including corticosteroids and retinoids, have shown limited success. This case is notable for its rarity, especially in females, who typically exhibit milder symptoms.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 14 results

      community My skin is always dry and flakes like chalk (25)

      in Transgender  6 upvotes 7 months ago
      The user underwent a biopsy two years ago and was diagnosed with keratosis pilaris, leading to hair issues. They tried treatments including Minoxidil, betamethasone, lymecycline, topical Accutane, and dutasteride, as well as diet changes, without improvement in hair thickness or skin dryness.

      community What are these spots on my scalp

      in Treatment  51 upvotes 4 months ago
      A user noticed non-itchy, non-bleeding spots on their scalp while experiencing hair loss. Replies suggest the spots are likely sunspots or liver spots and recommend seeing a dermatologist; hair loss is attributed to male pattern baldness.

      community My Experience and a Discourse on "DUPA"

      in Treatment  9 upvotes 5 months ago
      The user discusses their hair loss experience, exploring various hypotheses including thyroid levels, vitamin D, DHEA, nutritional deficiency, diabetes, seborrheic dermatitis, lack of nutrition to hair follicles, chronic inflammation, female pattern hair loss causes, cortisol, and prolactin levels. They are currently using finasteride, beta-sitosterol, and have tried topical dutasteride and microneedling therapy.

      community The hardest hair protocol ever!

      in Research/Science  9 upvotes 2 years ago
      The user is using RU58841, finasteride, dutasteride, and minoxidil to slow down aggressive hair loss but is still experiencing hair shedding due to high testosterone levels. They plan to use ostarine to lower testosterone and prevent hair loss while maintaining muscle mass, and will continue using the other treatments.

    Related Research

    5 / 5 results