Sex Hormones in SARS-CoV-2 Susceptibility: Key Players or Confounders?

    December 2022 in “ Nature Reviews Endocrinology ”
    Nicola Lott, Caroline E. Gebhard, Susan Bengs, Ahmed Haider, Gabriela M. Kuster, Vera Regitz‐Zagrosek, Cathérine Gebhard
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    TLDR Sex hormones' effects on COVID-19 are unclear and more research is needed to understand their potential as treatment.
    The review article "Sex hormones in SARS-CoV-2 susceptibility: key players or confounders?" explores the role of sex hormones, including androgens, oestrogens, and progesterone, in the regulation of virus entry receptors and the progression of COVID-19. The article indicates that there is no definitive evidence that sex-specific expression of virus entry receptors contributes to the observed sex disparities in COVID-19 outcomes. The effects of these hormones on the course of COVID-19 have yielded inconsistent results, and current data do not support the use of oestradiol or deprivation of androgens in COVID-19 treatment. The authors conclude that more research is needed to clarify the potential therapeutic value of these hormones in COVID-19.
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