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    Glossary Protein Structure

    three-dimensional shape of a protein determining its function

    Protein structure refers to the three-dimensional arrangement of atoms within a protein molecule. This structure is crucial because it determines the protein's function in biological processes. Proteins fold into specific shapes, which can be described at four levels: primary (sequence of amino acids), secondary (local folding into alpha-helices and beta-sheets), tertiary (overall 3D shape), and quaternary (assembly of multiple protein subunits). Proper folding is essential for the protein's activity, and misfolding can lead to diseases.

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      community Blocking dht should bring it back. So why does fin mostly just hold the line?

       17 upvotes 3 months ago
      Finasteride mainly prevents further hair loss by blocking DHT but doesn't reverse existing damage, while minoxidil can promote regrowth by waking dormant follicles. Ketoconazole helps with inflammation, but none of these treatments can reverse fibrosis or structural changes around hair follicles.

      community Verteporfin and Microneedling

      in Treatments 2 years ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community We should actually be hopeful for these recent new developments

       112 upvotes 1 year ago
      AI advancements, like AlphaFold, are speeding up drug discovery for hair loss, promising more effective treatments. Current options like minoxidil and finasteride have limitations, but new developments could improve solutions in 5-10 years.

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