Sequence And Structure Based Assessment Of Non-Synonymous SNPs In Hypertrichosis Universalis

    April 2012 in “ Bioinformation ”
    Rabiya Waheed, Mohammad Haroon Khan, Raisa Bano, Hamid Rashid
    Image of study
    TLDR Two specific SNPs in the TRPS1 gene cause excessive hair growth by altering the protein's structure.
    The study investigated the role of non-synonymous SNPs in the TRPS1 gene, which is linked to congenital hypertrichosis, a condition of excessive hair growth. Using SIFT and PolyPhen servers, SNPs rs181507248 and rs146506752 were identified as damaging. Structural analysis revealed that these SNPs significantly altered the secondary and tertiary structures and physiochemical properties of the TRPS1 protein, affecting its interactions and leading to the condition. The refined structure of TRPS1 was submitted to the Protein Model Database with ID PM0077843.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results

      community Dutasteride Literally Saves Your Hair

      in Finasteride/Dutasteride  101 upvotes 1 year ago
      Dutasteride significantly reduces scalp DHT levels and can save hair, though shedding is part of the process. Some users report success with dutasteride, while others struggle despite using it along with finasteride and oral minoxidil.

      community Why does it seem everyone favors finasteride over dutasteride?

      in Female  62 upvotes 1 year ago
      The conversation discusses preferences for hair loss treatments, specifically finasteride over dutasteride. Users share personal experiences, cost considerations, FDA approval status, and potential side effects, with some switching between treatments to find what works best for them.

      community Nuclear Stack Ineffective: Oral DUT/FIN/MIN/RU - NAFLD?

      in Finasteride/Dutasteride  1 upvotes 1 year ago
      The user experienced severe hair shedding despite using oral finasteride, minoxidil, dutasteride, and RU58841, and was diagnosed with Non-Alcoholic Fatty Liver Disease (NAFLD). They are considering switching to topical treatments due to the ineffectiveness of their current regimen.

      community Is this true? Is long term taking fin harmful to the liver?

      in Chat  127 upvotes 2 years ago
      The conversation discusses whether long-term use of finasteride (Fin) is harmful to the liver, with various opinions on side effects and comparisons to other substances. Specific treatments mentioned include finasteride, minoxidil (Min), and RU58841 (RU).

    Similar Research

    5 / 1000+ results