3 citations,
April 2012 in “Bioinformation” The study investigated the role of non-synonymous SNPs in the TRPS1 gene, which is linked to congenital hypertrichosis, a condition of excessive hair growth. Using SIFT and PolyPhen servers, SNPs rs181507248 and rs146506752 were identified as damaging. Structural analysis revealed that these SNPs significantly altered the secondary and tertiary structures and physiochemical properties of the TRPS1 protein, affecting its interactions and leading to the condition. The refined structure of TRPS1 was submitted to the Protein Model Database with ID PM0077843.
July 2022 in “New Zealand journal of agricultural research” The KRTAP27-1 gene variations in sheep may affect wool length and weight.
May 2023 in “Pharmaceuticals” Three specific mutations in the LIPH gene can cause hair loss by damaging the protein's structure and function.
92 citations,
December 2016 in “Scientific Reports” Researchers identified genes linked to coat color, body size, cashmere production, and high altitude adaptation in goats.
234 citations,
November 2009 in “American journal of human genetics” Common variants in the Trichohyalin gene are linked to straight hair in Europeans.