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    Glossary Protein Degradation

    process of breaking down proteins into amino acids

    Protein degradation is the process by which cells break down proteins into their constituent amino acids. This is essential for regulating protein levels, removing damaged or misfolded proteins, and recycling amino acids for new protein synthesis. In the context of hair and alopecia, disruptions in protein degradation pathways can affect hair follicle health and contribute to hair loss.

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    1. Protein degradation: expanding the toolbox to restrain cancer drug resistance Journal of Hematology & Oncology · 2023 · 7 citations
    2. Targeted protein degradation of Wnt/β-catenin signaling pathway: an effective strategy for cancer therapy Journal of Translational Medicine · 2025 · 8 citations
    3. De Novo-Designed Bifunctional Proteins for Targeted Protein Degradation Journal of the American Chemical Society · 2026
    4. De novo designed bifunctional proteins for targeted protein degradation 2026
    5. Proteolysis‐targeting chimeras in cancer therapy: Targeted protein degradation for next‐generation treatment Cancer · 2025 · 3 citations
    6. <i>De novo</i> designed bifunctional proteins for targeted protein degradation 2025
    7. Recent Advances in Peptide Drug Discovery: Novel Strategies and Targeted Protein Degradation Pharmaceutics · 2024 · 15 citations
    8. Emerging Strategies in Smart Nano-PROTAC for Stimuli-Responsive Protein Degradation and Precision Cancer Therapy Nano Biomedicine and Engineering · 2025 · 6 citations
    9. Peptide-Based PROTACs: Transitioning from Static Paradigm to a Dynamic Landscape within Targeted Protein Degradation Bioconjugate Chemistry · 2026
    10. Age-Related Changes in Hair Shaft Protein Profiling and Genetically Variant Peptides Forensic Science International Genetics · 2020 · 17 citations
    11. Characterization of Soluble Protein Extracts from Keratinized Tissues: identification of Ubiquitin Universally Distributed in Hair, Nail, and Stratum Corneum Bioscience Biotechnology and Biochemistry · 2001 · 10 citations
    12. Autophagy Controls the Protein Composition of Hair Shafts 2023 · 2 citations
    13. 1430 Autophagy controls the protein composition of hair shafts Journal of Investigative Dermatology · 2023
    14. Resistance Training Ameliorates Finasteride-Induced Disturbance in Protein Homeostasis in Skeletal Muscle of Rats 운동과학 · 2019 · 2 citations
    15. An Electron Microscopy Study of Keratin Degradation by the Fungus Microsporum gypseum in vitro Mycoses · 2009 · 30 citations
    16. The Mixed Lineage Kinase Leucine-Zipper Protein Kinase Exhibits a Differentiation-Associated Localization in Normal Human Skin and Induces Keratinocyte Differentiation upon Overexpression Journal of Investigative Dermatology · 2000 · 17 citations
    17. Crystallin Fusion Proteins Improve the Thermal Properties of Hair Frontiers in bioengineering and biotechnology · 2019 · 7 citations
    18. 1335 Maintenance of epidermal progenitor function through the mRNA degradation and translation pathways Journal of Investigative Dermatology · 2018
    19. Experimental study on the compatibility and degradation of human hair keratin bridging for peripheral nerve defects Zhonghua chuangshang guke zazhi · 2005
    20. The effect of various cosmetic pretreatments on protecting hair from thermal damage by hot flat ironing. PubMed · 2011 · 29 citations
    21. Comparative Proteomic Analysis in Scar-Free Skin Regeneration in Acomys cahirinus and Scarring Mus musculus Scientific Reports · 2020 · 13 citations
    22. Identification of compound heterozygous mutations in <i>AP1B1</i> leading to the newly described recessive keratitis–ichthyosis–deafness (KIDAR) syndrome British Journal of Dermatology · 2021 · 11 citations
    23. Molecular elements of the regulatory control of keratin filament modulator AHF/trichohyalin in the hair follicle Experimental Dermatology · 2008 · 7 citations
    24. Tailored Effects of Plasma-Activated Water on Hair Structure Through Comparative Analysis of Nitrate-Rich and Peroxide-Rich Formulations Across Different Hair Types Applied Sciences · 2025
    25. Recovery and protection of photo‐damaged hairs with keratin‐encapsulated cationic liposomes International Journal of Cosmetic Science · 2025
    26. Research Progress in Composition, Classification and Influencing Factors of Hair Asian journal of beauty & cosmetology · 2023
    27. Oxidative Modification in Human Hair: The Effect of the Levels of Cu (II) Ions, UV Exposure and Hair Pigmentation Photochemistry and photobiology · 2015 · 16 citations
    28. 저항훈련은 랫 골격근에서 finasteride에 의해 유도된 단백질 항상성 교란을 개선시킨다 운동과학 · 2019
    29. The physical and chemical disruption of human hair after bleaching – studies by transmission electron microscopy and redox proteomics International Journal of Cosmetic Science · 2018 · 30 citations
    30. Impact of oxidative hair coloring and bleaching on hair fiber properties Brazilian Journal of Hair Health · 2026