ADAM17 Variant Causes Hair Loss via Ubiquitin Ligase TRIM47 Mediated Degradation

    May 2024 in “ JCI insight ”
    Xiaoxiao Wang, Chaolan Pan, Luyao Zheng … Ming Li
    Studysummary In this study, researchers discovered a dominant variant in the ADAM17 gene that causes hypotrichosis with woolly hair, where the mutation leads to hair follicle stem cell exhaustion and abnormal hair follicles, resulting in alopecia.
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