Transient Stimulation of TRPV4-Expressing Keratinocytes Promotes Hair Follicle Regeneration in Mice

June 2020 in “ British Journal of Pharmacology ”

Pu Yang, Ping Lu, Jialie Luo, Lixia Du, Jing Feng, Tao Cai, Yi Yuan, Hunter Cheng, Hongzhen Hu

TRPV4 keratinocytes hair follicle regeneration anagen-promoting growth factors GSK1016790A ERK signaling alopecia

TLDR Activating TRPV4 in skin cells helps regrow hair in mice, possibly offering a treatment for hair loss.

The study found that transient activation of TRPV4-expressing keratinocytes promotes hair follicle regeneration in mice by increasing the expression of anagen-promoting growth factors and downregulating the expression of growth factors that inhibit anagen. The action of GSK1016790A relies largely on the function of TRPV4 in skin and involves activation of downstream ERK signaling. The study suggests that TRPV4 activation could be a potential therapeutic target for hair loss and alopecia.

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Research cited in this study

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research Influence of TRPV3 Mutation on Hair Growth Cycle in Mice

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The TRPV3 gene mutation affects hair growth by keeping mice in the growth phase longer, which could help treat hair loss.

research Molecular Principles of Hair Follicle Induction and Morphogenesis

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