Transient Stimulation of TRPV4-Expressing Keratinocytes Promotes Hair Follicle Regeneration in Mice

    June 2020 in “ British Journal of Pharmacology ”
    Pu Yang, Ping Lu, Jialie Luo … Hongzhen Hu
    Studysummary This study found that activating TRPV4 in the skin of mice induced hair follicle regeneration by promoting anagen transition, suggesting potential treatment strategies for hair loss.
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    Research cited in this study 13

    1. TRPV4 Is Expressed in Human Hair Follicles and Inhibits Hair Growth In Vitro Journal of Investigative Dermatology · 2018
    2. Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF Nature Communications · 2017
    3. TRP Channels in Skin Biology and Pathophysiology Pharmaceuticals · 2016
    4. Effects of Imiquimod on Hair Follicle Stem Cells and Hair Cycle Progression ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2016
    5. Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations Cell · 2015
    6. Competitive Balance of Intrabulge BMP/Wnt Signaling Reveals a Robust Gene Network Ruling Stem Cell Homeostasis and Cyclic Activation Proceedings of the National Academy of Sciences · 2013
    7. VEGF Induces Proliferation of Human Hair Follicle Dermal Papilla Cells Through VEGFR-2-Mediated Activation of ERK Experimental Cell Research · 2012
    8. Activation of Transient Receptor Potential Vanilloid-3 Inhibits Human Hair Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2011
    9. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    10. Influence of TRPV3 Mutation on Hair Growth Cycle in Mice Biochemical and Biophysical Research Communications · 2007
    11. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    12. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    13. The Biology of Hair Follicles The New England Journal of Medicine · 1999

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