Transient Stimulation of TRPV4-Expressing Keratinocytes Promotes Hair Follicle Regeneration in Mice

June 2020 in “ British Journal of Pharmacology ”

Pu Yang, Ping Lu, Jialie Luo, Lixia Du, Jing Feng, Tao Cai, Yi Yuan, Hunter Cheng, Hongzhen Hu

TRPV4 keratinocytes hair follicle regeneration anagen-promoting growth factors GSK1016790A ERK signaling alopecia

TLDR Activating TRPV4 in skin cells helps regrow hair in mice, possibly offering a treatment for hair loss.

The study found that transient activation of TRPV4-expressing keratinocytes promotes hair follicle regeneration in mice by increasing the expression of anagen-promoting growth factors and downregulating the expression of growth factors that inhibit anagen. The action of GSK1016790A relies largely on the function of TRPV4 in skin and involves activation of downstream ERK signaling. The study suggests that TRPV4 activation could be a potential therapeutic target for hair loss and alopecia.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

research Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF

117 citations, March 2017 in “Nature Communications”

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

research TRP Channels in Skin Biology and Pathophysiology

124 citations, December 2016 in “Pharmaceuticals”

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

research Effects of Imiquimod on Hair Follicle Stem Cells and Hair Cycle Progression

25 citations, July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

Imiquimod cream activates hair follicle stem cells and causes early hair growth by changing immune cells and certain protein expressions.

research Activation of Transient Receptor Potential Vanilloid-3 Inhibits Human Hair Growth

105 citations, May 2011 in “The journal of investigative dermatology/Journal of investigative dermatology”

Activating TRPV3 stops human hair growth.

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

314 citations, April 2010 in “Developmental Cell”

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

research Influence of TRPV3 Mutation on Hair Growth Cycle in Mice

59 citations, September 2007 in “Biochemical and Biophysical Research Communications”

The TRPV3 gene mutation affects hair growth by keeping mice in the growth phase longer, which could help treat hair loss.

research Molecular Principles of Hair Follicle Induction and Morphogenesis

479 citations, January 2005 in “BioEssays”

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations, January 2001 in “Cell”

Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.

research The Biology of Hair Follicles

1113 citations, August 1999 in “The New England Journal of Medicine”

Hair follicle biology advancements may lead to better hair growth disorder treatments.

Related Community Posts Join

3 / 3 results

community Progress pictures. 2 months on Fin, 4 on Min.

in Progress Pictures 191 upvotes 2 months ago

The user experienced significant hair regrowth after using Finasteride for 2 months and Minoxidil for 4 months, along with a derma roller. They reported no side effects from the treatments and noted that Finasteride seemed to contribute most to the progress.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

in Research/Science 1 upvotes 2 weeks ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 411 upvotes 2 weeks ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

Related Research

4 / 4 results

Transient Stimulation of TRPV4-Expressing Keratinocytes Promotes Hair Follicle Regeneration in Mice