Transient Stimulation of TRPV4-Expressing Keratinocytes Promotes Hair Follicle Regeneration in Mice

    June 2020 in “ British Journal of Pharmacology ”
    Pu Yang, Ping Lu, Jialie Luo, Lixia Du, Jing Feng, Tao Cai, Yi Yuan, Hunter Cheng, Hongzhen Hu
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    Studysummary This study found that activating TRPV4 in the skin of mice induced hair follicle regeneration by promoting anagen transition, suggesting potential treatment strategies for hair loss. Our plain-language summary of this paper — not a Tressless recommendation.
    The study found that transient activation of TRPV4-expressing keratinocytes promotes hair follicle regeneration in mice by increasing the expression of anagen-promoting growth factors and downregulating the expression of growth factors that inhibit anagen. The action of GSK1016790A relies largely on the function of TRPV4 in skin and involves activation of downstream ERK signaling. The study suggests that TRPV4 activation could be a potential therapeutic target for hair loss and alopecia.
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