In Vivo Monitoring of Survival and Proliferation of Hair Stem Cells in Hair Follicle Regeneration Animal Model

    Jung Hyun Kim, Byeong-Cheol Ahn, Ho Nyung Lee, Mi-Hye Hwang, Seng Hyun Shin, Sang Yup Lee, Young Chul Sung, Jaetae Lee
    Image of study
    TLDR Hair stem cells were tracked in mice using a special imaging technique, showing that it's possible to monitor hair growth this way.
    This study aimed to investigate the in vivo trafficking of hair follicle stem cells using non-invasive bioluminescence imaging. The researchers established hair follicle stem cells expressing a reporter gene called effluc and transplanted them into nude mice. They then used bioluminescence imaging to track the survival and proliferation of these cells over time. The results showed that the bioluminescence signal from the transplantation site decreased gradually over two weeks and then plateaued. Hair follicle regeneration was confirmed at the implantation site, demonstrating the feasibility of monitoring hair generation using this imaging strategy in an animal model.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Best Microneedle Lengths To Stimulate Stem Cells

      in Microneedling  18 upvotes 1 year ago
      Microneedling with needle lengths of 1.5mm to 2.5mm to stimulate hair follicle stem cells for potential hair growth. Using needles longer than 2.5mm is not recommended due to risk of puncturing veins in the scalp. A dermastamp is suggested over a roller.

      community New molecule PP405 vs exercise

      in Research/Science  36 upvotes 2 months ago
      PP405 targets hair follicle stem cells differently than exercise-induced lactate, suggesting exercise alone may not replicate its benefits. Minoxidil and finasteride are recommended alongside exercise for hair regrowth, with additional suggestions like spicy food and infrared exposure.

      community TDM-105795 phase 2 results are in!

      in Research/Science  28 upvotes 1 year ago
      TDM-105795 showed promising hair growth results, with higher efficacy than placebo and minimal side effects. It activates dormant hair follicle stem cells and may maintain gains without immediate loss, unlike minoxidil.

      community GT20029 and PP405 the new fin and min that we been waiting for ?

      in Chat  31 upvotes 6 days ago
      PP405 and GT20029 are new hair loss treatments with different mechanisms from traditional options like Minoxidil and Finasteride. PP405 targets hair follicle stem cells to reactivate growth, while GT20029 works as an androgen receptor deleter, both requiring ongoing use for effectiveness.

    Related Research

    6 / 6 results