Mechanical Force Drives the Initial Mesenchymal-Epithelial Interaction During Skin Organoid Development

    January 2023 in “ Theranostics ”
    Mengyue Wang, Xintao Zhou, Siyi Zhou … Mingxing Lei
    Studysummary This study demonstrated that a mechanical-chemical cascade involving dermal cell contraction and the activation of Piezo1 in epidermal cells is crucial for initiating interactions necessary for hair follicle regeneration in skin organoids.
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    Research cited in this study 9

    1. Mapping the Molecular and Structural Specialization of the Skin Basement Membrane for Inter-Tissue Interactions Nature communications · 2021
    2. Tissue Mechanics in Haired Murine Skin: Potential Implications for Skin Aging Frontiers in Cell and Developmental Biology · 2021
    3. Skin Cyst: A Pathological Dead-End With a New Twist of Morphogenetic Potentials in Organoid Cultures Frontiers in cell and developmental biology · 2021
    4. Tp63-Expressing Adult Epithelial Stem Cells Cross Lineage Boundaries Revealing Latent Hairy Skin Competence Nature Communications · 2020
    5. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020
    6. Mechanical Stretch Induces Hair Regeneration Through the Alternative Activation of Macrophages Nature Communications · 2019
    7. Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids Cell Reports · 2018
    8. Getting to the Core of the Dermal Papilla Journal of Investigative Dermatology · 2017
    9. Self-Organization Process in Newborn Skin Organoid Formation Inspires Strategy to Restore Hair Regeneration of Adult Cells Proceedings of the National Academy of Sciences of the United States of America · 2017

    Related research 2

    1. Long-Term Expansion and Differentiation of Adult Murine Epidermal Stem Cells in 3D Organoid Cultures Proceedings of the National Academy of Sciences · 2019
    2. Cutaneous Stem Cells: Something New and Something Borrowed Wound Repair and Regeneration · 2007