(-)-Cannabidiol Differentially Influences Hair Growth

The study from October 1, 2017, examined the impact of (-)-cannabidiol (CBD) on human hair follicles. It found that CBD at low concentrations (0.1-1 μM) encouraged hair growth, whereas high concentrations (10 μM) inhibited growth and led to an early transition to the catagen phase, as well as an increase in apoptotic cell ratio in the hair matrix. The research identified that the growth-promoting effects of CBD were associated with adenosine receptor activation, which also prevented the up-regulation of pro-inflammatory cytokines. In contrast, the pro-catagen effects were linked to TRPV4-dependent calcium influx, reduced cell count, and induced cell death. The study concluded that CBD influences hair growth through different receptors, with varying outcomes based on the concentration used.