Regulatory Effect of Cannabidiol on Decreased β-Catenin Expression in Alopecia Models by Testosterone and PMA Treatment in Dermal Papilla Cells

June 2021 in “ Journal of pharmacopuncture ”

Yoon-Jong Park, Jae-Min Ryu, Han-Heom Na, Hyun Suk Jung, Bok-hye Kim, Jin‐Sung Park, Byung-Soo Ahn, Keun-Cheol Kim

Cannabidiol CBD β-catenin alopecia testosterone PMA dermal papilla cells hormonal alopecia hair loss hormonal hair loss

Studysummary This study found that while CBD did not change gene expression including β-catenin in hair follicles, it restored decreased β-catenin expression in dermal papilla cells affected by testosterone or PMA, suggesting a potential modulating function on alopecia.

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The research investigated the impact of Cannabidiol (CBD) on β-catenin expression, a protein crucial for hair growth, in alopecia models. The study found that β-catenin expression, which is often decreased in alopecia, was restored with CBD treatment in dermal papilla cells treated with testosterone and PMA. The research suggests that CBD could potentially modulate alopecia caused by hormonal or excess signaling pathway, indicating a potential application for alopecia treatment. However, it was also noted that CBD treatment slightly inhibited cell growth after a 3-day incubation.

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