The Hair Loss Encyclopedia

Case Study of Hair Regrowth with Topical Cannabidiol

July 2021 in “ Hair transplant forum international ”

Gregory L. Smith, John Satino

topical cannabidiol CBD hemp oil androgenetic alopecia CB1 receptor antagonist Wnt signaling finasteride minoxidil CBD oil Propecia Rogaine

TLDR Daily use of CBD-rich hemp oil significantly increased hair growth in people with hair loss.

A study involving 35 subjects (28 men and 7 women) with androgenetic alopecia (AGA) found that daily topical application of a CBD-rich hemp oil resulted in a significant 93.5% increase in nonvellus hair after 6 months, with men and the vertex area showing slightly better results. The study suggested that CBD likely functions as a CB1 receptor antagonist and may also involve Wnt signaling, contributing to hair regrowth. No adverse effects were reported, and the results were comparable to those of finasteride and 5% minoxidil, indicating potential for synergistic use with these treatments.

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Research cited in this study

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The Phytocannabinoid (–)-Cannabidiol Operates as a Complex, Differential Modulator of Human Hair Growth: Anti-Inflammatory Submicromolar Versus Hair Growth Inhibitory Micromolar Effects

research The Phytocannabinoid (–)-Cannabidiol Operates as a Complex, Differential Modulator of Human Hair Growth: Anti-Inflammatory Submicromolar Versus Hair Growth Inhibitory Micromolar Effects

15 citations , July 2019 in “Journal of Investigative Dermatology”

CBD can either reduce inflammation and not affect hair growth at low levels or inhibit hair growth at high levels.

research Cannabinoid Signaling in the Skin: Therapeutic Potential of the Cutaneous Cannabinoid System

142 citations , March 2019 in “Molecules/Molecules online/Molecules annual”

Cannabinoids may help treat various skin conditions.

A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia

research A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia

43 citations , July 2018 in “Journal of The European Academy of Dermatology and Venereology”

Finasteride and minoxidil mix works better for hair growth than minoxidil alone, with similar safety.

Frequency, Severity, and Related Factors of Androgenetic Alopecia in Dermatology Outpatient Clinic: Hospital-Based Cross-Sectional Study in Turkey

research Frequency, Severity, and Related Factors of Androgenetic Alopecia in Dermatology Outpatient Clinic: Hospital-Based Cross-Sectional Study in Turkey

37 citations , February 2017 in “Anais Brasileiros De Dermatologia”

AGA more common in men, increases with age, linked to family history, hypertension, dyslipidemia, and smoking.

Male Androgenetic Alopecia: Population-Based Study in 1,005 Subjects

research Male Androgenetic Alopecia: Population-Based Study in 1,005 Subjects

41 citations , January 2009 in “International Journal of Trichology”

58% of men aged 30-50 have hair loss, with severity increasing with age.

research Hair Cycle Control by Vanilloid Receptor-1 (TRPV1): Evidence from TRPV1 Knockout Mice

49 citations , April 2006 in “Journal of Investigative Dermatology”

TRPV1 helps regulate hair growth cycles.