Case Study of Hair Regrowth with Topical Cannabidiol

July 2021 in “ Hair transplant forum international ”

Gregory L. Smith, John Satino

topical cannabidiol CBD hemp oil androgenetic alopecia CB1 receptor antagonist Wnt signaling finasteride minoxidil CBD oil Propecia Rogaine

From the encyclopedia

Finasteride →

Frontline, gold standard treatment for combatting androgenic alopecia

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Studysummary This study found a 93.5% increase in nonvellus hair after 6 months of daily topical CBD application on the scalp in individuals with androgenetic alopecia, with no reported adverse effects.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

A study involving 35 subjects (28 men and 7 women) with androgenetic alopecia (AGA) found that daily topical application of a CBD-rich hemp oil resulted in a significant 93.5% increase in nonvellus hair after 6 months, with men and the vertex area showing slightly better results. The study suggested that CBD likely functions as a CB1 receptor antagonist and may also involve Wnt signaling, contributing to hair regrowth. No adverse effects were reported, and the results were comparable to those of finasteride and 5% minoxidil, indicating potential for synergistic use with these treatments.

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Research cited in this study

6 / 6 results

The Phytocannabinoid (–)-Cannabidiol Operates as a Complex, Differential Modulator of Human Hair Growth: Anti-Inflammatory Submicromolar Versus Hair Growth Inhibitory Micromolar Effects

research The Phytocannabinoid (–)-Cannabidiol Operates as a Complex, Differential Modulator of Human Hair Growth: Anti-Inflammatory Submicromolar Versus Hair Growth Inhibitory Micromolar Effects

15 citations , July 2019 in “Journal of Investigative Dermatology”

This exploratory study found that cannabidiol (CBD) at higher concentrations may inhibit hair growth by promoting the onset of catagen in human hair follicles, while lower concentrations showed potential anti-inflammatory effects without promoting catagen.

research Cannabinoid Signaling in the Skin: Therapeutic Potential of the Cutaneous Cannabinoid System

142 citations , March 2019 in “Molecules/Molecules online/Molecules annual”

This review discusses the role of the endocannabinoid system in skin health and disease, highlighting its potential for future research and applications, but reports no new experimental results.

A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia

research A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia

43 citations , July 2018 in “Journal of The European Academy of Dermatology and Venereology”

This study found that a topical solution combining 0.25% finasteride with 3% minoxidil significantly improved hair growth, as measured by hair density, diameter, and global assessment, in men with androgenetic alopecia, compared to 3% minoxidil alone, over 24 weeks without systemic adverse effects reported.

Frequency, Severity, and Related Factors of Androgenetic Alopecia in Dermatology Outpatient Clinic: Hospital-Based Cross-Sectional Study in Turkey

research Frequency, Severity, and Related Factors of Androgenetic Alopecia in Dermatology Outpatient Clinic: Hospital-Based Cross-Sectional Study in Turkey

37 citations , February 2017 in “Anais Brasileiros De Dermatologia”

In this study, researchers found that the prevalence of androgenetic alopecia was higher in their sample compared to other studies in Asian and Caucasian populations, and it was linked with age-related severity.

research Male Androgenetic Alopecia: Population-Based Study in 1,005 Subjects

41 citations , January 2009 in “International Journal of Trichology”

This study found that 58% of men aged 30-50 had androgenic alopecia, with disease severity increasing with age and many being candidates for medical treatment or hair transplantation.

research Hair Cycle Control by Vanilloid Receptor-1 (TRPV1): Evidence from TRPV1 Knockout Mice

49 citations , April 2006 in “Journal of Investigative Dermatology”

TRPV1 helps regulate hair growth cycles.