How Cannabidiol Supports Hair Growth: From Epigenetics to the Scalp Microbiome

    November 2025 in “ Journal of Investigative Dermatology ”
    I Kamholtz, SI Gaumond, R. Aggarwal, Jj Jimenez, I Kamholtz, SI Gaumond, R. Aggarwal, Jj Jimenez
    TLDR CBD can help hair grow by supporting scalp health and reducing inflammation.
    Cannabidiol (CBD) supports hair growth through various mechanisms, including modulation of receptors like CB1 and TRPV1, promoting keratinocyte proliferation, stem cell migration, and anti-inflammatory responses. It enhances anagen phase at low doses but may induce catagen phase at higher concentrations. CBD restores follicular immune privilege by upregulating TGF-β and IL-10, inhibiting inflammatory pathways, and enhancing Wnt/β-catenin signaling for stem cell activation. Epigenetically, it upregulates DNMT1 and key histone marks, while suppressing certain microRNAs to support follicular integrity. Additionally, CBD modulates the scalp microbiome by inhibiting pathogenic bacteria and reducing sebum production, which helps maintain immune privilege. Overall, CBD offers a dose-dependent therapeutic strategy for hair growth and follicular homeostasis.
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