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    GlossaryScleroderma (Systemic Sclerosis)

    chronic autoimmune disease causing skin and connective tissue hardening

    Scleroderma, also known as systemic sclerosis, is a chronic autoimmune disease characterized by the hardening and tightening of the skin and connective tissues. It can affect not only the skin but also internal organs such as the heart, lungs, kidneys, and digestive tract, leading to a range of symptoms from mild to life-threatening. The exact cause is unknown, but it involves an overproduction of collagen, leading to fibrosis and vascular abnormalities.

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      community Why is it so hard to select one

      in Satire  645 upvotes 7 months ago
      Choosing hair loss treatments is challenging due to concerns about side effects from finasteride and minoxidil. Users suggest starting with topical treatments and gradually increasing dosage, while some recommend oral finasteride for its effectiveness despite potential side effects.

      community find a cure for this shit already

      in Chat  208 upvotes 4 years ago
      Treatments used to prevent and treat male pattern baldness, the difficulty in finding a permanent cure for hair loss, and the potential financial motivations of companies not wanting to find a cure.

      community How much Minoxidil goes systemic?

      in Minoxidil  61 upvotes 1 day ago
      The conversation is about the systemic absorption of Minoxidil and the potential switch from topical to oral Minoxidil due to its effectiveness. The user considers oral Minoxidil after experiencing no side effects from a year of using 15% topical Minoxidil.

      community Does ketoconazole reduce systemic DHT by much?

      in Treatment  7 upvotes 2 days ago
      Ketoconazole shampoo does not significantly reduce systemic or scalp DHT levels and is mainly used for its anti-fungal and anti-inflammatory effects. It is not a replacement for finasteride, which is recommended by some users despite concerns about side effects.