Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90

August 2016 in “ American Journal Of Pathology ”

Banafsheh Nazari, Lisa Rice, Giuseppina Stifano, Alex Barron, Yu Mei Wang, Tess Korndorf, Jung Eun Lee, Jag Bhawan, Robert Lafyatis, Jeffrey L. Browning

dermal fibroblasts systemic sclerosis podoplanin CD90 CD34 TNF IL-1β fibrotic processes

TLDR Fibroblast changes in systemic sclerosis may help understand disease severity and treatment.

The study examined changes in dermal fibroblasts in systemic sclerosis (SSc), focusing on the transition from CD34+ to podoplanin+ (Pdpn) and CD90+ fibroblasts. This transition was observed in 48 diffuse and 24 limited cutaneous SSc patients compared to 11 healthy controls, and was more extensive in SSc than in other inflammatory skin diseases. The findings suggested that inflammatory stimuli like TNF and IL-1β could induce this fibroblast transition, which was associated with disease severity and fibrotic processes. The study highlighted the complexity of fibroblast differentiation in SSc and suggested that these changes might provide insights into early disease events and aid in patient staging and treatment evaluation.

View this study on ajp.amjpathol.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community It’s crazy how it’s 2018 and the only hair loss treatments we have feature undesirable side effects and/or aren’t even effective for many people.

136 upvotes 6 years ago

Hair loss treatments, including minoxidil, dermarolling, finasteride, dutasteride, hair transplants, hair systems, and shaving the head. The conversation covers various opinions on these treatments and mentions possible side effects as well as alternatives like wigs, vitamins, and lifestyle changes. The post expresses disappointment that there has been no major breakthrough in the field of hair loss treatments despite decades of research.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 1 year ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community How does dutasteride regrowth work?

in Finasteride/Dutasteride 6 upvotes 6 months ago

A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

community How all hormones affect our hair follicles. Not just DHT. Take a look at this paper. Prolactin, melatonin, cortisol, progesterone, testosterone and more

in Research/Science 126 upvotes 2 years ago

The conversation discusses various factors affecting hair loss, not just DHT, and mentions treatments like Minoxidil, finasteride, and melatonin. Some users report personal experiences with these treatments and hormone tests, while others speculate on the role of hormones like prolactin and cortisol in hair loss.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 732 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community This serum outperformed Minoxidil in a recent study. Please debunk

23 upvotes 5 years ago

A topical solution called "Multi-Peptide Serum for Hair Density" by The Ordinary Company, which contains several ingredients that are used in alternatives to Minoxidil and was found to have better results than 5% Minoxidil in a study. People who have tried it shared their experiences with the serum as well.

Similar Research

5 / 1000+ results

research SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin

225 citations, April 2018 in “Journal of Investigative Dermatology”

Two main types of fibroblasts with unique functions and additional subtypes were identified in human skin.

research Defining Skin Fibroblastic Cell Types Beyond CD90

31 citations, October 2018 in “Frontiers in Cell and Developmental Biology”

The conclusion is that CD90 is not a specific marker for fibroblast subtypes and better methods are needed to identify them.

research Fibroblasts: Origins, Definitions, and Functions in Health and Disease

488 citations, July 2021 in “Cell”

Fibroblasts are crucial for tissue repair and inflammation, and understanding them can help treat fibrotic diseases.

research Cutaneous and Mucosal Lichen Planus: A Comprehensive Review of Clinical Subtypes, Risk Factors, Diagnosis, and Prognosis

291 citations, January 2014 in “The Scientific World Journal”

Lichen Planus is a less common condition affecting skin and mucous membranes, with various types and associated risk factors, challenging to diagnose, significantly impacts life quality, and may have a risk of cancerous changes in oral lesions.

research Lymphatic Vessel: Origin, Heterogeneity, Biological Functions, and Therapeutic Targets

3 citations, January 2024 in “Signal transduction and targeted therapy”

Lymphatic vessels are essential for health and can be targeted to treat various diseases.