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GlossaryBRCA1

gene involved in DNA repair, linked to cancer risk

BRCA1 is a gene that produces a protein responsible for repairing damaged DNA, playing a crucial role in maintaining the genetic stability of cells. Mutations in the BRCA1 gene can lead to a significantly increased risk of developing breast and ovarian cancers, as the defective protein fails to properly repair DNA, allowing genetic mutations to accumulate.

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research Uterus Hyperplasia and Increased Carcinogen-Induced Tumorigenesis in Mice Carrying a Targeted Mutation of the Chk2 Phosphorylation Site in Brca1

48 citations , October 2004 in “Molecular and Cellular Biology”

Mice with a specific BRCA1 mutation have a higher risk of tumors, especially in the uterus and ovaries.

research One of These Things Is Not Like the Others: The Idea of Precedence in Health Technology Assessment and Coverage Decisions

35 citations , June 2005 in “The Milbank Quarterly”

The conclusion is that formalizing how past decisions influence current health technology assessments could improve the credibility and defense of coverage decisions.

research Rare Germline Pathogenic Variants Identified by Multigene Panel Testing and the Risk of Aggressive Prostate Cancer

20 citations , March 2021 in “Cancers”

Certain genetic variants increase the risk of aggressive prostate cancer.

research Dysregulated Behavior of Hair Follicle Stem Cells Triggers Alopecia and Provides Potential Therapeutic Targets

3 citations , May 2022 in “Experimental Dermatology”

Misbehaving hair follicle stem cells can cause hair loss and offer new treatment options.

research Case Study: Hereditary Cancer Genetic Testing in Unaffected Patients May Allow for Early Intervention and Aggressive Management

October 2014 in “Journal of Minimally Invasive Gynecology”

Genetic testing for cancer risk can lead to early and life-saving treatments in people without symptoms.

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community One and a half year on meds (fin/dut, minox)

in Progress Pictures 54 upvotes 1 year ago

The user has been using oral minoxidil, finasteride, and dutasteride to prevent hair loss, despite not showing significant balding. Many commenters believe the treatment is excessive, while some support early prevention.

community [AMA] 5-Month Progress Report: Dutasteride and Oral Minoxidil Results.

in Minoxidil 70 upvotes 4 years ago

Naepo's 5-month progress report detailing their journey of treating male pattern baldness with dutasteride and oral minoxidil, which has already resulted in an encouraging improvement in hair density. Others have responded with appreciation for the thorough report and asked further questions about Naepo's educational background.