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    Glossary BRCA1

    gene involved in DNA repair, linked to cancer risk

    BRCA1 is a gene that produces a protein responsible for repairing damaged DNA, playing a crucial role in maintaining the genetic stability of cells. Mutations in the BRCA1 gene can lead to a significantly increased risk of developing breast and ovarian cancers, as the defective protein fails to properly repair DNA, allowing genetic mutations to accumulate.

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    1. BRCA2 in abscission Nature Cell Biology · 2012
    2. Commentary on BRCA1-Associated Protein-1 Tumor Predisposition Syndrome in a Patient With Numerous Basal Cell Carcinomas Dermatologic Surgery · 2019
    3. Uterus Hyperplasia and Increased Carcinogen-Induced Tumorigenesis in Mice Carrying a Targeted Mutation of the Chk2 Phosphorylation Site in Brca1 Molecular and Cellular Biology · 2004 · 48 citations
    4. One of These Things Is Not Like the Others: The Idea of Precedence in Health Technology Assessment and Coverage Decisions The Milbank Quarterly · 2005 · 35 citations
    5. Testosterone levels in relation to oral contraceptive use and the androgen receptor CAG and GGC length polymorphisms in healthy young women Human Reproduction · 2006 · 25 citations
    6. Rare Germline Pathogenic Variants Identified by Multigene Panel Testing and the Risk of Aggressive Prostate Cancer Cancers · 2021 · 20 citations
    7. Dysregulated behaviour of hair follicle stem cells triggers alopecia and provides potential therapeutic targets Experimental Dermatology · 2022 · 3 citations
    8. Case Study: Hereditary Cancer Genetic Testing in Unaffected Patients May Allow for Early Intervention and Aggressive Management Journal of Minimally Invasive Gynecology · 2014
    9. HRT for women with premature ovarian insufficiency: a comprehensive review Human Reproduction Open · 2017 · 61 citations
    10. CPC12 Coinheritance of <i>BRCA2</i> and <i>CYLD</i> germline pathogenic variants associated with targetable metastatic malignant cylindroma British Journal of Dermatology · 2023
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