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GlossaryBRCA2

gene involved in DNA repair and cancer risk

BRCA2 is a gene that produces a protein responsible for repairing damaged DNA, playing a crucial role in maintaining the genetic stability of cells. Mutations in the BRCA2 gene can lead to an increased risk of developing certain cancers, most notably breast and ovarian cancer, as the impaired DNA repair mechanism allows for the accumulation of genetic errors.

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research BRCA2 in Abscission: Role in Cytokinesis and Recruitment of Abscission Regulators

August 2012 in “Nature Cell Biology”

The tumor suppressor BRCA2 helps in cell division by bringing key proteins to the area where cells split.

research Coinheritance of BRCA2 and CYLD Germline Pathogenic Variants Associated with Targetable Metastatic Malignant Cylindroma

June 2023 in “British Journal of Dermatology”

Coinheritance of BRCA2 and CYLD genes may lead to new treatment options for certain cancers.

research Rare Germline Pathogenic Variants Identified by Multigene Panel Testing and the Risk of Aggressive Prostate Cancer

20 citations , March 2021 in “Cancers”

Certain genetic variants increase the risk of aggressive prostate cancer.

research Case Study: Hereditary Cancer Genetic Testing in Unaffected Patients May Allow for Early Intervention and Aggressive Management

October 2014 in “Journal of Minimally Invasive Gynecology”

Genetic testing for cancer risk can lead to early and life-saving treatments in people without symptoms.

research Ductal Breast Cancer in a Male Patient

October 2010 in “International Journal of Dermatology”

An 86-year-old man with prostate cancer was diagnosed with a rare, low-grade breast cancer and underwent surgery but declined additional hormone therapy.

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community One and a half year on meds (fin/dut, minox)

in Progress Pictures 54 upvotes 1 year ago

The user has been using oral minoxidil, finasteride, and dutasteride to prevent hair loss, despite not showing significant balding. Many commenters believe the treatment is excessive, while some support early prevention.

community [AMA] 5-Month Progress Report: Dutasteride and Oral Minoxidil Results.

in Minoxidil 75 upvotes 4 years ago

Naepo's 5-month progress report detailing their journey of treating male pattern baldness with dutasteride and oral minoxidil, which has already resulted in an encouraging improvement in hair density. Others have responded with appreciation for the thorough report and asked further questions about Naepo's educational background.