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    Glossary BRCA2

    gene involved in DNA repair and cancer risk

    BRCA2 is a gene that produces a protein responsible for repairing damaged DNA, playing a crucial role in maintaining the genetic stability of cells. Mutations in the BRCA2 gene can lead to an increased risk of developing certain cancers, most notably breast and ovarian cancer, as the impaired DNA repair mechanism allows for the accumulation of genetic errors.

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    Research 30 of 203

    1. BRCA2 in abscission Nature Cell Biology · 2012
    2. Commentary on BRCA1-Associated Protein-1 Tumor Predisposition Syndrome in a Patient With Numerous Basal Cell Carcinomas Dermatologic Surgery · 2019
    3. Uterus Hyperplasia and Increased Carcinogen-Induced Tumorigenesis in Mice Carrying a Targeted Mutation of the Chk2 Phosphorylation Site in Brca1 Molecular and Cellular Biology · 2004 · 48 citations
    4. One of These Things Is Not Like the Others: The Idea of Precedence in Health Technology Assessment and Coverage Decisions The Milbank Quarterly · 2005 · 35 citations
    5. Testosterone levels in relation to oral contraceptive use and the androgen receptor CAG and GGC length polymorphisms in healthy young women Human Reproduction · 2006 · 25 citations
    6. Rare Germline Pathogenic Variants Identified by Multigene Panel Testing and the Risk of Aggressive Prostate Cancer Cancers · 2021 · 20 citations
    7. CPC12 Coinheritance of <i>BRCA2</i> and <i>CYLD</i> germline pathogenic variants associated with targetable metastatic malignant cylindroma British Journal of Dermatology · 2023
    8. Case Study: Hereditary Cancer Genetic Testing in Unaffected Patients May Allow for Early Intervention and Aggressive Management Journal of Minimally Invasive Gynecology · 2014
    9. Ductal breast cancer in a male patient International Journal of Dermatology · 2010
    10. HRT for women with premature ovarian insufficiency: a comprehensive review Human Reproduction Open · 2017 · 61 citations
    11. Dysregulated behaviour of hair follicle stem cells triggers alopecia and provides potential therapeutic targets Experimental Dermatology · 2022 · 3 citations
    12. Relationships, Intimacy, & Body Image After Breast Cancer Oncology times · 2016
    13. Outcomes in Clinically Relevant Patient Subgroups From the EMBRACA Study: Talazoparib vs Physician’s Choice Standard-of-Care Chemotherapy JNCI Cancer Spectrum · 2019 · 26 citations
    14. Chromatographic Method for Simultaneous Quantification of Gemcitabine and Olaparib Recovered from Isolated Pancreatic Tissue Chemistry · 2026
    15. Clinical Management of Prostate Cancer in High-Risk Genetic Mutation Carriers Cancers · 2022 · 10 citations
    16. Issue information Cancer · 2013
    17. 2022 Update on Prostate Cancer Epidemiology and Risk Factors—A Systematic Review European Urology · 2023 · 710 citations
    18. Prostate Cancer Early Detection, Version 2.2015 Journal of the National Comprehensive Cancer Network · 2015 · 67 citations
    19. Synchronizing actin and microtubules for axonal branching Nature Cell Biology · 2012 · 3 citations
    20. Replicative stress, stem cells and aging Mechanisms of Ageing and Development · 2008 · 70 citations
    21. Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss Cell Stem Cell · 2007 · 688 citations
    22. Evidence or Experience: That is the Question American Journal of Clinical Dermatology · 2014
    23. Tracing the cellular origin of cancer Nature Cell Biology · 2013 · 232 citations
    24. Adenomatous Polyposis Coli (APC) Is Required for Normal Development of Skin and Thymus PLoS Genetics · 2006 · 184 citations
    25. Selenoproteins Are Essential for Proper Keratinocyte Function and Skin Development PLoS ONE · 2010 · 101 citations
    26. YAP and TAZ are essential for basal and squamous cell carcinoma initiation EMBO Reports · 2018 · 76 citations
    27. Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis Cell death and differentiation · 2011 · 76 citations
    28. Long-term use of 5α-reductase inhibitors and the risk of male breast cancer Cancer Causes & Control · 2014 · 28 citations
    29. Candidate SNP markers of reproductive potential are predicted by a significant change in the affinity of TATA-binding protein for human gene promoters BMC Genomics · 2018 · 16 citations
    30. Finasteride and Male Breast Cancer: Does the MHRA Report Show a Link? PubMed · 2010 · 12 citations