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    Glossary BRCA1

    gene involved in DNA repair, linked to cancer risk

    BRCA1 is a gene that produces a protein responsible for repairing damaged DNA, playing a crucial role in maintaining the genetic stability of cells. Mutations in the BRCA1 gene can lead to a significantly increased risk of developing breast and ovarian cancers, as the defective protein fails to properly repair DNA, allowing genetic mutations to accumulate.

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    Research 30 of 189

    1. BRCA2 in abscission Nature Cell Biology · 2012
    2. Commentary on BRCA1-Associated Protein-1 Tumor Predisposition Syndrome in a Patient With Numerous Basal Cell Carcinomas Dermatologic Surgery · 2019
    3. Uterus Hyperplasia and Increased Carcinogen-Induced Tumorigenesis in Mice Carrying a Targeted Mutation of the Chk2 Phosphorylation Site in Brca1 Molecular and Cellular Biology · 2004 · 48 citations
    4. One of These Things Is Not Like the Others: The Idea of Precedence in Health Technology Assessment and Coverage Decisions The Milbank Quarterly · 2005 · 35 citations
    5. Testosterone levels in relation to oral contraceptive use and the androgen receptor CAG and GGC length polymorphisms in healthy young women Human Reproduction · 2006 · 25 citations
    6. Rare Germline Pathogenic Variants Identified by Multigene Panel Testing and the Risk of Aggressive Prostate Cancer Cancers · 2021 · 20 citations
    7. Dysregulated behaviour of hair follicle stem cells triggers alopecia and provides potential therapeutic targets Experimental Dermatology · 2022 · 3 citations
    8. Case Study: Hereditary Cancer Genetic Testing in Unaffected Patients May Allow for Early Intervention and Aggressive Management Journal of Minimally Invasive Gynecology · 2014
    9. HRT for women with premature ovarian insufficiency: a comprehensive review Human Reproduction Open · 2017 · 61 citations
    10. CPC12 Coinheritance of <i>BRCA2</i> and <i>CYLD</i> germline pathogenic variants associated with targetable metastatic malignant cylindroma British Journal of Dermatology · 2023
    11. Relationships, Intimacy, & Body Image After Breast Cancer Oncology times · 2016
    12. Ductal breast cancer in a male patient International Journal of Dermatology · 2010
    13. Outcomes in Clinically Relevant Patient Subgroups From the EMBRACA Study: Talazoparib vs Physician’s Choice Standard-of-Care Chemotherapy JNCI Cancer Spectrum · 2019 · 26 citations
    14. Chromatographic Method for Simultaneous Quantification of Gemcitabine and Olaparib Recovered from Isolated Pancreatic Tissue Chemistry · 2026
    15. Clinical Management of Prostate Cancer in High-Risk Genetic Mutation Carriers Cancers · 2022 · 10 citations
    16. Issue information Cancer · 2013
    17. 2022 Update on Prostate Cancer Epidemiology and Risk Factors—A Systematic Review European Urology · 2023 · 710 citations
    18. Prostate Cancer Early Detection, Version 2.2015 Journal of the National Comprehensive Cancer Network · 2015 · 67 citations
    19. Synchronizing actin and microtubules for axonal branching Nature Cell Biology · 2012 · 3 citations
    20. Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss Cell Stem Cell · 2007 · 688 citations
    21. Replicative stress, stem cells and aging Mechanisms of Ageing and Development · 2008 · 70 citations
    22. Evidence or Experience: That is the Question American Journal of Clinical Dermatology · 2014
    23. The human keratins: biology and pathology Histochemistry and Cell Biology · 2008 · 1398 citations
    24. Distinct stem cells contribute to mammary gland development and maintenance Nature · 2011 · 721 citations
    25. Tracing the cellular origin of cancer Nature Cell Biology · 2013 · 232 citations
    26. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014 · 175 citations
    27. Polymorphisms of the Androgen Receptor Gene and the Estrogen Receptor β Gene Are Associated with Androgen Levels in Women1 The Journal of Clinical Endocrinology and Metabolism · 2001 · 93 citations
    28. Edible seeds from Cucurbitaceae family as potential functional foods: Immense promises, few concerns Biomedicine & Pharmacotherapy · 2017 · 54 citations
    29. Profiling the Response of Human Hair Follicles to Ultraviolet Radiation Journal of Investigative Dermatology · 2009 · 53 citations
    30. Expression and roles of steroidogenic acute regulatory (StAR) protein in ‘non-classical’, extra-adrenal and extra-gonadal cells and tissues Molecular and Cellular Endocrinology · 2013 · 48 citations