TLDR TLR2 helps control hair growth and regeneration, and its reduction with age or obesity can impair hair growth.
The study explores the role of Toll-like receptor 2 (TLR2) in hair follicle (HF) cycle regulation and regeneration via BMP signaling. It shows that TLR2, activated by the PUFA metabolite CEP, promotes hair regeneration and growth, with TLR2 levels declining with age and obesity. TLR2 is essential for HF stem cell (HFSC) activation and hair cycle progression, as its deletion delays the onset of the anagen phase. TLR2 knockout mice exhibited prolonged telogen phases and reduced HFSC proliferation due to elevated BMP signaling, which Noggin, a BMP antagonist, could reverse. The findings suggest targeting TLR2 and its ligands could be a therapeutic strategy for treating hair loss and enhancing hair regeneration.
21 citations
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May 2022 in “Frontiers in Cell and Developmental Biology” Hair growth and health are influenced by factors like age, environment, and nutrition, and are controlled by various molecular pathways. Red light can promote hair growth, and understanding these processes can help treat hair-related diseases.
21 citations
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May 2016 in “Experimental and Therapeutic Medicine” MMP-2 and MMP-9 help hair grow, while their inhibitors peak when hair growth slows.
April 2016 in “Journal of Investigative Dermatology” Wnt ligands, produced by dermal papilla cells, are essential for adult hair growth and regeneration.
158 citations
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February 2012 in “Journal of Investigative Dermatology” FGF18 helps keep hair in its resting phase, affecting hair growth cycles.
17 citations
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December 2010 in “Journal of Investigative Dermatology” Flightless I protein affects hair growth, with low levels delaying it and high levels increasing hair length in rodents.
95 citations
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July 2006 in “British Journal of Dermatology” Vitamin D receptors in hair follicles change with the hair cycle, affecting hair growth.
