Hair growth relies on mechanical forces, not just chemicals, with tissue acting like a motor. Minoxidil and finasteride help, but maintaining tissue elasticity and addressing mechanical issues are essential.
Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.
How Finasteride and Dutasteride help reduce hair loss by reducing the amount of DHT in scalp areas, as well as discussing factors such as sensitivity to DHT, 5α-reductase expression in different parts of the hairfollicle, and scalp tension.
A new technique developed by scientists in Japan to reverse balding using hairfollicle cell transplants, and the discussion around the effectiveness of this approach compared to other treatments such as Minoxidil, finasteride, RU58841, Replicel, and Hairclone.
Dutasteride 0.5 mg significantly reduces both scalp and hairfollicle DHT, with a greater reduction in hairfollicle DHT. The discussion questions which reduction is more important for androgenetic alopecia and diffuse thinning.