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    Glossary Hair Follicle Sheath

    protective layer surrounding and supporting the hair follicle

    The hair follicle sheath is a protective layer that surrounds the hair follicle, which is the structure in the skin where hair grows. It consists of an inner and outer layer that help support and nourish the hair as it develops, playing a crucial role in the health and growth of hair.

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    1. Nestin expression in hair follicle sheath progenitor cells Proceedings of the National Academy of Sciences · 2003 · 352 citations
    2. Human Hair Follicle-Derived Mesenchymal Stromal Cells from the Lower Dermal Sheath as a Competitive Alternative for Immunomodulation Biomedicines · 2022 · 7 citations
    3. Morphometric prediction of mesenchymal stromal cell-like immunosuppressive capacity of human hair follicle dermal sheath cup cells: an implication for regenerative medicine in hair loss diseases Stem Cell Research & Therapy · 2025
    4. 862 Defining the molecular signature of the hair follicle dermal sheath and its functional requirement for hair cycle progression during catagen Journal of Investigative Dermatology · 2017
    5. K6irs1, K6irs2, K6irs3, and K6irs4 Represent the Inner-Root-Sheath-Specific Type II Epithelial Keratins of the Human Hair Follicle1 Journal of Investigative Dermatology · 2003 · 130 citations
    6. K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) Represent the Type I Inner Root Sheath Keratins of the Human Hair Follicle Journal of Investigative Dermatology · 2006 · 93 citations
    7. Keratins 1 and 10 or homologues as regular constituents of inner root sheath and cuticle cells in the human hair follicle. PubMed · 1990 · 44 citations
    8. Experimental Modulation of the Differentiated Phenotype of Keratinocytes from Epidermis and Hair Follicle Outer Root Sheath and Matrix Cells Annals of the New York Academy of Sciences · 1991 · 31 citations
    9. Functional analysis of keratin components in the mouse hair follicle inner root sheath British Journal of Dermatology · 2004 · 23 citations
    10. Synthesis of porcine pCLCA2 protein during late differentiation of keratinocytes of epidermis and hair follicle inner root sheath 2012 · 13 citations
    11. Melanocytes from the Outer Root Sheath of Hair Follicles Cultivated on Collagen Membrane Improve their Melanotic Properties Journal of Tissue Science & Engineering · 2012 · 5 citations
    12. Culturing of Melanocytes from the Equine Hair Follicle Outer Root Sheath Processes · 2021 · 1 citations
    13. Role of the Wnt/β-Catenin Signaling Pathway in Mediating Outer Root Sheath Stem Cells to Promote Hair Follicle Regeneration and Skin Wound Healing in Mice Cells · 2026
    14. 889 Trpv3 gain-of-function mutation impairs differentiation of hair follicle inner root sheath 2019
    15. Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla Journal of Investigative Dermatology · 2003 · 208 citations
    16. Keratins of the human hair follicle: “Hyperproliferative” keratins consistently expressed in outer root sheath cells in vivo and in vitro Differentiation · 1987 · 135 citations
    17. A Novel Epithelial Keratin, hK6irs1, is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells (Flügelzellen) of the Human Hair Follicle Journal of Investigative Dermatology · 2002 · 86 citations
    18. Solid basal cell epithelioma (BCE) possibly originates from the outer root sheath of the hair follicle. PubMed · 1993 · 61 citations
    19. Outer root sheath keratinization in anagen and catagen of the mammalian hair follicle. A seventh distinct type of keratinization in the hair follicle: trichilemmal keratinization. PubMed · 1981 · 59 citations
    20. Dynamic ultrastructural changes of the connective tissue sheath of human hair follicles during hair cycle Archives of Dermatological Research · 1990 · 44 citations
    21. VEGF165 modulates proliferation, adhesion, migration and differentiation of cultured human outer root sheath cells from central hair follicle epithelium through VEGFR-2 activation in vitro Journal of Dermatological Science · 2013 · 35 citations
    22. Structural features of the α-type filaments of the inner root sheath cells of the guinea pig hair follicle Biochemistry · 1978 · 24 citations
    23. Heparanase 1: a key participant of inner root sheath differentiation program and hair follicle homeostasis Experimental Dermatology · 2008 · 22 citations
    24. Double-stranded RNA induces inflammation via the NF-κB pathway and inflammasome activation in the outer root sheath cells of hair follicles Scientific reports · 2017 · 22 citations
    25. Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles Acta dermato-venereologica · 2018 · 11 citations
    26. Expression of E6 and E7 papillomavirus oncogenes in the outer root sheath of hair follicles extends the growth phase and bypasses resting at telogen. PubMed · 2000 · 10 citations
    27. Sex hormones and antiandrogens influence in vitro growth of dermal papilla cells and outer root sheath keratinocytes of human hair follicles 1993 · 9 citations
    28. Premature Desquamation of the Inner Root Sheath in Noninflamed Hair Follicles as a Specific Marker for Central Centrifugal Cicatricial Alopecia The American Journal of Dermatopathology · 2018 · 6 citations
    29. Connective tissue sheath of hair follicle is a major source of dermal type I procollagen in human scalp Journal of dermatological science · 2012 · 4 citations
    30. Cytochemistry of Trichohyalin Granules: A Possible Role for Cornification of Inner Root Sheath Cell in the Hair Follicle The Journal of Dermatology · 1989 · 4 citations