The Type I Keratin 19 Possesses Distinct and Context-Dependent Assembly Properties

December 1998 in “ Journal of Biological Chemistry ”

Julie Fradette, Lucie Germain, Partha Seshaiah, Pierre A. Coulombe

keratin 19 keratin 14 keratin 5 intermediate filament basal cells epithelial cell lines skin epithelia

Studysummary This study found that keratin 19, unlike keratin 14, forms less stable filaments with keratin 5, suggesting distinct assembly properties and potential unique roles in skin basal cells.

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research Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development

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research Directed Expression of Keratin 16 to the Progenitor Basal Cells of Transgenic Mouse Skin Delays Skin Maturation

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In a transgenic mouse model, this study found that overexpression of keratin 16 in skin keratinocytes led to hyperkeratosis and increased EGF receptor signaling, altering skin cell behavior and structure.

research Keratin 19 as a Biochemical Marker of Skin Stem Cells In Vivo and In Vitro: Localization and Variation with Age and Culture Stage

441 citations , May 1996 in “Journal of Cell Science”

This study found that keratin 19 may be a marker for skin stem cells, helping to characterize these cells in different conditions and potentially explaining variations in healing rates between children and adults.

research Localization of Merkel Cells at Hairless and Hairy Human Skin Sites Using Keratin 18

28 citations , September 1995 in “Biochemistry and Cell Biology”

This study localized Merkel cells in human skin, finding them in the basal layer of glabrous skin at palms and soles, and in the interfollicular epidermis and isthmus region of hair follicles.

research Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation

198 citations , November 1989 in “The Journal of Cell Biology”

This study reported that K14 expression patterns and keratin filament organization in human skin's hair follicles differ from those in the epidermis, indicating distinct differentiation programs.

research Keratin 19: Predicted Amino Acid Sequence and Broad Tissue Distribution Suggest It Evolved from Keratinocyte Keratins

238 citations , May 1989 in “Journal of Investigative Dermatology”

research Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues: Human and Bovine Hair Follicles

248 citations , April 1988 in “Differentiation”

In this study, researchers observed that trichocytic and epithelial cytokeratins have distinct expression patterns within various human and bovine hair follicle cells, contributing to understanding hair follicle development and growth.