The Type I Keratin 19 Possesses Distinct and Context-Dependent Assembly Properties

    December 1998 in “ Journal of Biological Chemistry ”
    Julie Fradette, Lucie Germain, Partha Seshaiah, Pierre A. Coulombe
    TLDR Keratin 19 forms less stable and shorter filaments than keratin 14, giving unique traits to certain skin cells.
    The study investigated the assembly properties of type I keratin 19 (K19) compared to keratin 14 (K14) when paired with type II keratin 5 (K5) in vitro and in various cell lines. It was found that K5–K19 filaments were shorter and less stable than K5–K14 filaments, with K19 showing a lower affinity for K5. In transfected BHK-21 cells, K5–K19 did not form a filamentous array, unlike K5–K14, which formed a network of filaments. However, K19 could integrate into pre-existing keratin networks in epithelial cell lines without disrupting them. In PtK2 cells, K19 expression led to the collapse of the keratin network, but co-expression with K8, a natural partner for K19, restored filament formation. These findings highlighted the distinct and context-dependent assembly properties of K19, suggesting its limited ability to form stable filaments with K5 compared to K14.
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