Directed Expression of a Chimeric Type II Keratin Partially Rescues Keratin 5-null Mice

    May 2014 in “ Journal of Biological Chemistry ”
    David M. Alvarado, Pierre A. Coulombe
    Studysummary In this study, targeting the expression of a keratin KRT5/KRT8 chimeric cDNA in keratin-deficient mice partially restored structural defects in epidermal cells, but did not fully normalize skin health.
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    Research cited in this study 8

    1. Keratin Disorders: From Gene to Therapy Human molecular genetics online/Human molecular genetics · 2011
    2. Epidermolysis Bullosa Simplex: A Paradigm for Disorders of Tissue Fragility ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2009
    3. Epidermal Abnormalities and Increased Malignancy of Skin Tumors in Human Epidermal Keratin 8-Expressing Transgenic Mice The FASEB Journal · 2004
    4. The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16 ˜The œjournal of cell biology/˜The œJournal of cell biology · 1999
    5. Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development The Journal of Cell Biology · 1998
    6. Directed Expression of Keratin 16 to the Progenitor Basal Cells of Transgenic Mouse Skin Delays Skin Maturation The Journal of Cell Biology · 1998
    7. Increased Expression of Keratin 16 Causes Anomalies in Cytoarchitecture and Keratinization in Transgenic Mouse Skin The Journal of Cell Biology · 1994
    8. The Structure of Human Trichohyalin: Potential Multiple Roles as a Functional EF-Hand-Like Calcium-Binding Protein, a Cornified Cell Envelope Precursor, and an Intermediate Filament-Associated (Cross-Linking) Protein Journal of Biological Chemistry · 1993

    Related research 1

    1. Keratin and Skin Disorders Cell biology international · 1996