Mir-574-3p and Mir-125a-5p in Adipose-Derived Mesenchymal Stem Cell Exosomes Synergistically Target TGF-β1/Smad2 Signaling Pathway for the Treatment of Androgenic Alopecia

    Cong Ma, Ming Cheng, Ting Xiao, Ruiqun Qi, Xinghua Gao, Hong‐Duo Chen, Yan Wu, Xuegang Xu
    TLDR Two microRNAs in stem cell exosomes help treat hair loss by targeting a specific signaling pathway.
    This study explores the therapeutic potential of exosomes from adipose-derived mesenchymal stem cells (ADMSCs-Exo) in treating androgenetic alopecia (AGA) by targeting the TGF-β1/Smad2 signaling pathway. It identifies two microRNAs, miR-574-3p and miR-125a-5p, as crucial in inhibiting this pathway and counteracting the effects of dihydrotestosterone (DHT) on dermal papilla cells (DPCs). The research shows that knocking down these miRNAs significantly reduces the therapeutic efficacy of ADMSCs-Exo, underscoring their importance in the treatment process. These findings enhance understanding of AGA pathogenesis and suggest new therapeutic strategies, while also calling for further research into the roles and interactions of these miRNAs.
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