From Hair to Colon: Hair Follicle-Derived MSCs Alleviate Pyroptosis in DSS-Induced Ulcerative Colitis by Releasing Exosomes in a Paracrine Manner

January 2022 in “ Oxidative Medicine and Cellular Longevity ”

Yuan Chang, Yichi Zhang, Yanan Jiang, Lei Zhao, Lu Chengqian, Qianqian Huang, Jing-Ming Guan, S. Jin

hair follicle-derived mesenchymal stem cells HFMSCs exosomes pyroptosis TRAIL signaling pathway IFN-gamma signaling pathway hair follicle stem cells Exos

TLDR Hair follicle stem cells can help treat ulcerative colitis in mice by releasing beneficial exosomes.

The study demonstrates that hair follicle-derived mesenchymal stem cells (HFMSCs) can alleviate dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice by releasing exosomes (Exos) that inhibit pyroptosis, a form of programmed cell death. HFMSCs reduced the expression of pyroptosis-related proteins and improved cell viability, with the highest efficacy observed at a dose of 400 μg per mouse administered twice a week. The therapeutic effects are suggested to involve the TRAIL and IFN-gamma signaling pathways, highlighting HFMSCs and their Exos as a promising treatment for UC.

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