From Hair to Pancreas: Transplanted Hair Follicle Mesenchymal Stem Cells Express Pancreatic Progenitor Cell Markers in a Rat Model of Acute Pancreatitis

    January 2021 in “ PubMed
    Xiaoli Sun, Yang Gao, Haoyuan Chen, Ningning Yang, Yichi Zhang, Qi Liu, Yanan Jiang, Shizhu Jin
    TLDR Hair follicle stem cells may help treat acute pancreatitis by reducing inflammation and aiding regeneration.
    The study investigated the therapeutic potential of hair follicle-derived mesenchymal stem cells (HF-MSCs) in treating acute pancreatitis (AP) using a rat model. HF-MSCs were extracted from infant Sprague-Dawley rats and transplanted into rats with AP via tail vein injection. The results showed that HF-MSCs homed to the damaged pancreas, expressed pancreatic progenitor cell markers, reduced inflammation, and promoted pancreatic regeneration. These findings suggested that HF-MSC transplantation could be a promising treatment for AP, although further research on its effectiveness and safety was needed for clinical application.
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