Comparative Characterization and Osteogenic/Adipogenic Differentiation of Mesenchymal Stem Cells Derived from Male Rat Hair Follicles and Bone Marrow

August 2020 in “ Cell regeneration ”

Abdel Kader A. Zaki, Tariq I. Almundarij, Faten A. M. Abo-Aziza

mesenchymal stem cells hair follicles bone marrow adipogenic differentiation osteogenic differentiation lipid accumulation bone alkaline phosphatase activity calcium deposition MSCs HF-MSCs BM-MSCs

TLDR Hair follicle stem cells are similar to bone marrow stem cells but are better for fat cell research.

The study compared mesenchymal stem cells (MSCs) derived from male rat hair follicles (HF-MSCs) and bone marrow (BM-MSCs) in terms of their proliferation rates and differentiation potential. Both HF-MSCs and BM-MSCs exhibited similar cell yields, viability, and surface marker expressions, but HF-MSCs showed a higher proliferation rate. HF-MSCs demonstrated superior adipogenic differentiation with greater lipid accumulation, while BM-MSCs exhibited better osteogenic differentiation with higher bone alkaline phosphatase activity and calcium deposition. These findings suggested that HF-MSCs could be a viable and accessible alternative to BM-MSCs for regenerative medicine applications, particularly in adipogenesis.

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