Targeting Adult Mesenchymal Stem Cells Plasticity for Tissue Regeneration

    January 2017 in “ Stem Cells International ”
    Giorgio Mori, Giacomina Brunetti, Filiberto Mastrangelo, Elisabetta Ada Cavalcanti‐Adam
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    TLDR Adult mesenchymal stem cells can help regenerate tissues and are promising for healing bones, wounds, and hair follicles.
    The editorial from 2017 discusses the potential of adult mesenchymal stem cells (MSCs) for tissue regeneration, highlighting their ability to differentiate into various mature cell lineages and their role in healing injured tissue. It emphasizes the bone marrow as the standard source for harvesting MSCs, but also notes the promise of dental tissues, such as dental follicle and bud, for osteoblastic differentiation. The paper mentions the use of dental pulp stem cells in osteogenic differentiation, which can be enhanced by platelet lysate supplementation. Additionally, it covers the role of MSCs in wound healing and hair follicle regeneration, particularly through the overexpression of Wnt. The editorial also discusses the use of pulsed electromagnetic fields to promote osteogenic differentiation of bone marrow MSCs and the impact of the extracellular environment on MSC differentiation. It suggests that combining MSC priming with chemical modulators and 3D printing-based materials could be effective for treating cardiovascular disease and enhancing revascularization of grafts.
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