Morphometric Prediction of Mesenchymal Stromal Cell-Like Immunosuppressive Capacity of Human Hair Follicle Dermal Sheath Cup Cells: An Implication for Regenerative Medicine in Hair Loss Diseases

November 2025 in “ Stem Cell Research & Therapy ”

Hyuma Tsuji, Hsing Yi Lin, Suguru Kinoshita, Hidemasa Jinguji, Yosuke Nakazawa, Masashi Ogo, Manabu Ohyama

mesenchymal stromal cells human dermal sheath cup cells DSCCs hair follicle regeneration immunosuppressive capabilities microinflammation regenerative medicine

TLDR Human hair follicle cells can help regenerate hair and reduce inflammation, aiding in hair loss treatment.

The study indicates that human dermal sheath cup cells (DSCCs) have potential applications in regenerative medicine for hair loss diseases. These cells not only support hair follicle regeneration but also possess immunosuppressive capabilities that can mitigate microinflammation, a factor that may contribute to hair loss. The effectiveness of DSCCs in these roles can be efficiently assessed through a newly developed morphometric analysis.

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Research cited in this study

17 / 17 results

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Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss Using Dermal Sheath Cup Cells: A Randomized Placebo-Controlled Double-Blinded Dose-Finding Clinical Study

research Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss Using Dermal Sheath Cup Cells: A Randomized Placebo-Controlled Double-Blinded Dose-Finding Clinical Study

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research Wnt Activator CHIR99021-Stimulated Human Dermal Papilla Spheroids Contribute to Hair Follicle Formation and Production of Reconstituted Follicle-Enriched Human Skin

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research In Vitro Characterization of Human Hair Follicle Dermal Sheath Mesenchymal Stromal Cells and Their Potential in Enhancing Diabetic Wound Healing

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184 citations , November 2014 in “Developmental Cell”

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research Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege

53 citations , September 2013 in “Journal of Investigative Dermatology”

Hair follicle cells help protect against immune attacks by regulating T-cell activity.

Evaluation of Perifollicular Inflammation of Donor Area During Hair Transplantation in Androgenetic Alopecia and Its Comparison With Controls

research Evaluation of Perifollicular Inflammation of Donor Area During Hair Transplantation in Androgenetic Alopecia and Its Comparison With Controls

13 citations , January 2013 in “International Journal of Trichology”

Inflammation around hair follicles may worsen hair loss; evaluating and treating it can improve transplant results.

research Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling

300 citations , August 2012 in “Seminars in Cell & Developmental Biology”

The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.

research Female Pattern Hair Loss in Complete Androgen Insensitivity Syndrome

54 citations , February 2010 in “British Journal of Dermatology”

Hair loss in women may have causes other than hormones.

research The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization

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The document concludes that specific cells are essential for hair growth and more research is needed to understand how to maintain their hair-inducing properties.

research Comparative Characterization of Hair Follicle Dermal Stem Cells and Bone Marrow Mesenchymal Stem Cells

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research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

550 citations , December 2005 in “The Journal of clinical investigation/The journal of clinical investigation”

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Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

208 citations , December 2003 in “Journal of Investigative Dermatology”

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research Androgenetic Alopecia and Microinflammation

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

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in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community This guy claims stem cells fixed his balding

in Is this regrowth? 301 upvotes 2 years ago

A man who claimed to have regrown his hair using stem cell treatment, sparking a debate about its effectiveness and cost. Some users suggested he might be using other treatments or substances, while others shared their own experiences with stem cell therapy for hair loss.

community Mesenchymal Stem Cell Therapy (Exosome) Before & After

in Treatment 2 upvotes 1 year ago

A user's father experienced hair regrowth and other health improvements after two IV exosome treatments. The user also had four rounds of exosome therapy, noting significant hair regrowth and relief from headaches, but no change in gray hair.

community 1.5 Year Hair Restoration Journey - Stem Cells, PRP, Minoxidil, Topical Finasteride

in Progress Pictures 27 upvotes 1 year ago

A user shared their 1.5-year hair restoration journey, successfully using mesenchymal stem cell therapy, Platelet Rich Plasma (PRP) injections, and a topical compound of finasteride and minoxidil, avoiding a hair transplant and oral finasteride. They experienced significant hair regrowth, particularly crediting the stem cell therapy for quick initial results.

community Microneedling and aloe vera to recruit stem cells.

in Chat 11 upvotes 1 year ago

Microneedling combined with aloe vera may stimulate dormant stem cells in hair loss areas. Minoxidil is also suggested for better results.

community Lavdik Hair Growth Serum?

in Product 5 years ago

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