Establishment and Molecular Characterization of Human Dermal Mesenchymal-Like Stem Cells Derived from Human Scalp Biopsy of Androgenetic Alopecia Patient

January 2013 in “ Stem cell discovery ”

Pravin D. Potdar, Kavitha Ashok Kumar

human dermal mesenchymal-like stem cells androgenetic alopecia hair follicles CD34 Keratin 18 Oct4 Nanog SOX2 bulge region epithelial characteristics mesenchymal characteristics hDMSCs stem cells alopecia hair loss

Studysummary This study reports the creation of a human dermal mesenchymal-like stem cell line from an androgenetic alopecia patient, which may serve as an in vitro model to explore alopecia mechanisms. Our plain-language summary of this paper — not a Tressless recommendation.

The study established a human dermal mesenchymal-like stem cell line from a scalp biopsy of an androgenetic alopecia patient. These cells, termed "Human Dermal Mesenchymal-like Stem Cells (hDMSCs)," were derived from the bulge region of hair follicles and exhibited both epithelial and mesenchymal characteristics, expressing markers such as CD34, Keratin 18, Oct4, Nanog, and SOX2. The optimal growth conditions for these cells were found to be at a 3% serum concentration. The hDMSCs were maintained up to passage 10 and were proposed as an in vitro model to study the mechanisms of alopecia and related skin disorders.

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Research cited in this study

7 / 7 results

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This paper discusses key mechanisms of androgen metabolism in androgenetic alopecia and reports the effectiveness of treatments like oral finasteride and topical minoxidil, highlighting the limited success rate due to factors like follicular inflammation.