Osteogenic Potential of Mesenchymal Stem Cells from Adipose Tissue, Bone Marrow, and Hair Follicle Outer Root Sheath in a 3D Crosslinked Gelatin-Based Hydrogel

    May 2021 in “ International journal of molecular sciences ”
    Hanluo Li, Hafiz Awais Nawaz, Federica Francesca Masieri, Sarah Vogel, Ute Hempel, Alexander K. Bartella, Rüdiger Zimmerer, Jan‐Christoph Simon, Michaela Schulz‐Siegmund, Michael C. Hacker, Bernd Lethaus, Vuk Savković
    Studysummary This study demonstrated that autologous mesenchymal stem cells from hair follicles, when combined with a novel gelatin-based hydrogel, showed promising osteogenic potential and could offer a non-invasive alternative for bone regeneration. Our plain-language summary of this paper — not a Tressless recommendation.
    The study compared the osteogenic potential of mesenchymal stem cells (MSCs) derived from adipose tissue, bone marrow, and the hair follicle outer root sheath (MSCORS) within a 3D crosslinked gelatin-based hydrogel (Osteogel). MSCORS demonstrated superior osteogenic differentiation, evidenced by higher calcium deposition and expression of osteogenic markers, while maintaining high cell viability and alkaline phosphatase activity comparable to other MSCs. The findings suggested that MSCORS, which can be obtained non-invasively, combined with Osteogel, represent a promising approach for bone regeneration therapy due to their high osteogenic potential and the adaptability of the hydrogel for filling irregularly shaped lesions.
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