Osteogenic Potential of Mesenchymal Stem Cells from Adipose Tissue, Bone Marrow, and Hair Follicle Outer Root Sheath in a 3D Crosslinked Gelatin-Based Hydrogel

May 2021 in “ International journal of molecular sciences ”

Hanluo Li, Hafiz Awais Nawaz, Federica Francesca Masieri, Sarah Vogel, Ute Hempel, Alexander K. Bartella, Rüdiger Zimmerer, Jan‐Christoph Simon, Michaela Schulz‐Siegmund, Michael C. Hacker, Bernd Lethaus, Vuk Savković

hair follicle outer root sheath mesenchymal stem cells MSCORS osteogenic differentiation calcium deposition alkaline phosphatase activity

TLDR Stem cells from hair follicles in a special gel show strong potential for bone regeneration.

The study compared the osteogenic potential of mesenchymal stem cells (MSCs) derived from adipose tissue, bone marrow, and the hair follicle outer root sheath (MSCORS) within a 3D crosslinked gelatin-based hydrogel (Osteogel). MSCORS demonstrated superior osteogenic differentiation, evidenced by higher calcium deposition and expression of osteogenic markers, while maintaining high cell viability and alkaline phosphatase activity comparable to other MSCs. The findings suggested that MSCORS, which can be obtained non-invasively, combined with Osteogel, represent a promising approach for bone regeneration therapy due to their high osteogenic potential and the adaptability of the hydrogel for filling irregularly shaped lesions.

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