The Angiogenic Potential of Mesenchymal Stem Cells from the Hair Follicle Outer Root Sheath

    February 2021 in “ Journal of Clinical Medicine ”
    Vuk Savković, Hanluo Li, Danilo Obradović, Federica Francesca Masieri, Alexander K. Bartella, Rüdiger Zimmerer, Jan‐Christoph Simon, Christian D. Etz, Bernd Lethaus
    TLDR Hair follicle stem cells are promising for blood vessel formation and tissue repair.
    The study investigated the angiogenic potential of mesenchymal stem cells from the hair follicle outer root sheath (MSCORS) for vascular regeneration and tissue engineering. MSCORS were found to differentiate efficiently into endothelial and smooth muscle cells, essential for blood vessel formation, and showed superior performance compared to adipose-derived mesenchymal stem cells (ADMSCs). The study involved 7 healthy donors for hair follicles and 5 patients for adipose tissue. MSCORS-derived cells demonstrated a high capacity for forming complex angiogenic networks and expressed elevated levels of VEGF, a critical factor in angiogenesis. The findings highlighted MSCORS as a promising, non-invasive source for personalized regenerative therapies, with potential applications in tissue engineering and vascularization, although further optimization for in vivo applications was suggested.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 13 results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Anyone Try Microneedling with Exosomes/AAPE?

      in Microneedling  2 upvotes 2 years ago
      User asks where to purchase exosomes/AAPE for microneedling hair loss treatment. Links to research on hair regeneration therapy, stem cell therapy, exosome therapy, and dermal exosomes provided.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

    Related Research

    1 / 1 results