Hypoxia Enhances Differentiation of Hair Follicle-Associated Pluripotent Stem Cells to Cardiac Muscle Cells

    September 2016 in “ Journal of Cellular Biochemistry ”
    Kyoumi Shirai, Yuko Hamada, Nobuko Arakawa, Aiko Yamazaki, Natsuko Tohgi, Ryoichi Aki, Sumiyuki Mii, Robert M. Hoffman, Yasuyuki Amoh
    TLDR Low oxygen levels help hair follicle stem cells turn into heart muscle cells faster.
    The study demonstrated that hair-follicle-associated pluripotent (HAP) stem cells, which express the neural stem-cell marker nestin, could differentiate into various cell types, including cardiac muscle cells. Under hypoxic conditions, these HAP stem cells showed an increased rate of differentiation into troponin-positive cardiac-muscle cells compared to normoxic conditions. This finding suggested that hypoxia could enhance the differentiation process, potentially allowing for the use of a patient's own HAP stem cells for cardiac muscle regeneration. The study highlighted the potential of using HAP stem cells, which are easily accessible, for regenerative medicine, particularly in cardiac muscle repair.
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