Multipotent Nestin-Expressing Stem Cells Capable of Forming Neurons Are Located in the Upper, Middle, and Lower Part of the Vibrissa Hair Follicle

    August 2012 in “ Cell Cycle ”
    Yasuyuki Amoh, Sumiyuki Mii, Ryoichi Aki, Yuko Hamada, Katsumasa Kawahara, Robert M. Hoffman, Kensei Katsuoka
    TLDR Stem cells in hair follicles can become neurons and other cells, especially in the upper part, useful for nerve repair.
    The study demonstrated that multipotent, nestin-expressing stem cells were present throughout the vibrissa hair follicle, with the greatest differentiation potential in the upper part. These stem cells, identified using a transgenic mouse model, could differentiate into neurons, glia, keratinocytes, smooth muscle cells, and melanocytes. The upper part of the follicle produced a large number of spheres from nestin-expressing cells, which differentiated into various cell types, suggesting potential applications for nerve and spinal cord repair.
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